68419-38-5

Basic information

• Product Name: (R)-(+)-PIPERIDINE-2-ETHANOL
• Synonyms: (R)-(+)-PIPERIDINE-2-ETHANOL;(R)-2-(PIPERIDIN-2-YL)ETHANOL;(R)-2-Piperidineethanol;2-Piperidineethanol, (2R)-;(R)-2-(piperidin-2-yl)ethan-1-ol hydrochloride;2-[(2R)-piperidin-2-yl]ethanol
• CAS NO: 68419-38-5
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2001
• Product Categories: Amines;Chiral Reagents;Heterocycles
• Mol File: 68419-38-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 234.5°C at 760 mmHg
• Flash Point: 102.222°C
• Appearance: white crystalline powder
• Density: 0.939g/cm3
• Storage Temp.: 2-8°C(protect from light)
• PKA: 15.15±0.10(Predicted)
• CAS DataBase Reference: (R)-(+)-PIPERIDINE-2-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-PIPERIDINE-2-ETHANOL(68419-38-5)
• EPA Substance Registry System: (R)-(+)-PIPERIDINE-2-ETHANOL(68419-38-5)

Safety Data

• Hazardous Substances Data: 68419-38-5(Hazardous Substances Data)

Usage

Uses

(R)-(+)-PIPERIDINE-2-ETHANOL is useful in preparation of a novel class of pyrazolopyrimidines as inhibitors of protein and checkpoint kinases. And it is useful in treatment and prophylaxis of HCV infection and other diseases such as cancer.

Upstream product

• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 
• 327158-13-4 (R)-6-Allyl-1-[(R)-1-(2-hydroxy-phenyl)-ethyl]-piperidin-2-one 
• 327158-11-2 1-[(R)-1-(2-Hydroxy-phenyl)-ethyl]-piperidine-2,6-dione 
• 327158-12-3 (9aS,10R)-10-Methyl-1,2,3,9a-tetrahydro-10H-9-oxa-4a-aza-anthracen-4-one 
• 108-55-4 glutaric anhydride, 
• 327158-15-6 {(R)-1-[(R)-1-(2-Methoxy-phenyl)-ethyl]-6-oxo-piperidin-2-yl}-acetaldehyde 

Downstream Products

• 121524-18-3 (2R)-1-[3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acryloyl]-2-(2-hydroxyethyl)piperidine 
• 19832-04-3 (R)-2-(piperidin-2'-yl)ethanoic acid 
• 351410-32-7 (R)-2-(1-(tert-butoxycarbonyl)piperidin-2-yl) acetic acid 
• 813433-73-7 (R)-2-methoxycarbonylmethylpiperidine-1-carboxylic acid tert-butyl ester 
• 250249-85-5 (R)-2-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles

The scope, reactivity, and selectivity of the chiral hydroxamic acid-catalyzed kinetic resolution of chiral amines are improved by a new catalyst structure and a more environmentally friendly reaction protocol. In addition to increasing selectivity across all substrates, these conditions make possible the resolution of N-heterocycles containing lactams or other basic functional groups that can inhibit the catalyst.

Total synthesis of (-)-senepodine G and (-)-cermizine C

(Chemical Equation Presented) An efficient, stereospecific synthesis of the alkaloids senepodine G (2) and cermizine C (1) has been completed using the BF3·Et2O-promoted stereospecific addition of Me2CuLi to α,β-unsaturated lactam 6 to provide lactam 3, the addition of MeMgBr followed by HCl to convert 3 to senepodine G (2) (six steps, 40% overall yield), and the stereospecific NaBH4 reduction of 2 to give cermizine C (1) (seven steps, 40% overall yield).

Total synthesis of (-)-stellettamide B and determination of its absolute stereochemistry.

[figure: see text] The first total synthesis of (-)-stellettamide B has been achieved by a sequence based on amide coupling of the chiral 1-(aminomethyl)-indolizidine fragment, prepared by TiCl4-mediated asymmetric allylation of the tricyclic N-acyl-N,O-a