2-(Aminomethyl)piperidine

Base Information

• Chemical Name: 2-(Aminomethyl)piperidine
• CAS No.: 22990-77-8
• Molecular Formula: C6H14N2
• Molecular Weight: 114.191
• Hs Code.: 29333990
• European Community (EC) Number: 245-371-1
• UNII: 9Y4RLA45BH
• DSSTox Substance ID: DTXSID80945687
• Nikkaji Number: J43.049H
• Mol file: 22990-77-8.mol

Synonyms:22990-77-8;2-PIPERIDYLMETHYLAMINE;2-(Aminomethyl)piperidine;piperidin-2-ylmethanamine;2-Piperidinemethanamine;2-Aminomethylpiperidine;2-(AMINOMETHYL)-1-PIPERIDINE;Piperidine-2-methylamine;Piperidine, 2-(aminomethyl)-;2-Aminomethyl-1-piperidine;1-(piperidin-2-yl)methanamine;(RS)-(Piperidin-2-yl)methanamine;EINECS 245-371-1;EC 245-371-1;(piperidin-2-yl)methanamine;2-AMINOMETHYL PIPERIDINE;C-PIPERIDIN-2-YL-METHYLAMINE;Flecainide impurity B;2-aminomethyl-piperdine;2AMPPR;2-Piperidinylmethanamine #;9Y4RLA45BH;rac.-2-aminomethylpiperidine;SCHEMBL234569;AMY3381;DTXSID80945687;2-(Aminomethyl)piperidine, 97%;MFCD00129011;(RS)-1-(Piperidin-2-yl)methanamine;AKOS005207013;CS-W011240;SB41146;AC-31100;DS-12357;A4872;FT-0608726;EN300-51822;F13324;W-201960;Flecainide impurity B, European Pharmacopoeia (EP) Reference Standard

Chemical Property of 2-(Aminomethyl)piperidine

Chemical Property:

• Appearance/Colour: Colorless clear liquid.
• Vapor Pressure: 1.07mmHg at 25°C
• Refractive Index: 1.4850
• Boiling Point: 176.9 °C at 760 mmHg
• PKA: 10.32±0.29(Predicted)
• Flash Point: 66.7 °C
• PSA: 38.05000
• Density: 0.897 g/cm³
• LogP: 1.11630
• Storage Temp.: -20°C
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 114.115698455
• Heavy Atom Count: 8
• Complexity: 63.5

Purity/Quality:

99.9% ^*data from raw suppliers

2-Piperidinemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCNC(C1)CN
• Uses: 2-Piperidinemethanamine is used in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. It also is used in the synthesis of potent antibacterial. Reactant for reversible aminal formationReactant for synthesis of:Annulated N-heterocyclic carbene ligandsM3 Muscarinic receptor antagonistsSelective 5-ht5A receptor antagonistsTernary platinum(II) complexes

Technology Process of 2-(Aminomethyl)piperidine

There total 7 articles about 2-(Aminomethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.1%

2-(Aminomethyl)pyridine (3731-51-9) → C-piperidin-2-yl-methylamine (22990-77-8,111478-74-1,111478-77-4)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; water; for 2.5h; Ambient temperature;

DOI:10.1002/jps.2600790819

Reference yield:

2-Cyanopyridine (100-70-9,1232006-36-8) → C-piperidin-2-yl-methylamine (22990-77-8,111478-74-1,111478-77-4)

Guidance literature:

With ammonia; hydrogen; Ni-5584; In ethanol; at 180 ℃; for 6h; under 135014 Torr; Product distribution / selectivity;

Reference yield:

→ C-piperidin-2-yl-methylamine (22990-77-8,111478-74-1,111478-77-4)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01526a054

upstream raw materials:

2-(Aminomethyl)pyridine

hydrogenchloride

diethyl ether

phosphorus pentachloride

Downstream raw materials:

1,3-Dimethyl-4-phenyl-6,6a,7,8,9,10-hexahydro-1H-1,2,5,10a-tetraaza-benzo[e]azulene

4-(3-Chloro-phenyl)-1,3-dimethyl-6,6a,7,8,9,10-hexahydro-1H-1,2,5,10a-tetraaza-benzo[e]azulene

flecainide

flecainide hydrochloride