1H-Indole, 3-(2,2-diethoxyethyl)-4-(3-hydroxy-3-methyl-1-butenyl)-1-[(4-methylphen yl)sulfonyl]-, (E)-

Base Information

Chemical Name:1H-Indole, 3-(2,2-diethoxyethyl)-4-(3-hydroxy-3-methyl-1-butenyl)-1-[(4-methylphen yl)sulfonyl]-, (E)-
CAS No.:108948-27-2
Molecular Formula:C26H33NO5S
Molecular Weight:471.618
Hs Code.:
Mol file:108948-27-2.mol

Synonyms:

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Chemical Property of 1H-Indole, 3-(2,2-diethoxyethyl)-4-(3-hydroxy-3-methyl-1-butenyl)-1-[(4-methylphen yl)sulfonyl]-, (E)-

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Technology Process of 1H-Indole, 3-(2,2-diethoxyethyl)-4-(3-hydroxy-3-methyl-1-butenyl)-1-[(4-methylphen yl)sulfonyl]-, (E)-

There total 3 articles about 1H-Indole, 3-(2,2-diethoxyethyl)-4-(3-hydroxy-3-methyl-1-butenyl)-1-[(4-methylphen yl)sulfonyl]-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 115-18-4
2-methyl-3-buten-2-ol

: 108948-24-9
4-bromo-3-(2,2-diethoxyethyl)-1-tosylindole

: 108948-27-2
3-(2,2-diethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole

Guidance literature:: With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In acetonitrile; at 100 ℃; for 5h;
DOI:10.1021/jo00391a027

Reference yield:

: 90481-83-7
4-bromo-3-iodo-1-tosyl-1H-indole

: 108948-27-2
3-(2,2-diethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) dicyclopentadienylzirconium chloride, 2.) Ni(PPh₃)4 / 1.) benzene, RT, 2 h, 2.) THF, RT, 48 h

2: 1.) BBr₃*SMe₂, 2.) 1 M aq. NaHCO₃ / 1.) CH₂Cl₂, RT, 5 min, 2.) CH₂Cl₂, RT, 2.5 h

3: 92 percent / Pd(OAc)2, (o-tolyl)3P, Et₃N / acetonitrile / 5 h / 100 °C

With palladium diacetate; zirconocene dichloride; boron tribromide-dimethyl sulfide complex; tetrakis(triphenylphosphine)nickel⁽⁰⁾; sodium hydrogencarbonate; triethylamine; tris-(o-tolyl)phosphine; In acetonitrile;
DOI:10.1021/jo00391a027

Reference yield:

: 108948-23-8
4-bromo-3-(2-ethoxyethen-1-yl)-1-tosylindole

: 108948-27-2
3-(2,2-diethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) BBr₃*SMe₂, 2.) 1 M aq. NaHCO₃ / 1.) CH₂Cl₂, RT, 5 min, 2.) CH₂Cl₂, RT, 2.5 h

2: 92 percent / Pd(OAc)2, (o-tolyl)3P, Et₃N / acetonitrile / 5 h / 100 °C

With palladium diacetate; boron tribromide-dimethyl sulfide complex; sodium hydrogencarbonate; triethylamine; tris-(o-tolyl)phosphine; In acetonitrile;
DOI:10.1021/jo00391a027