Technology Process of 1H-Indole, 4-bromo-3-(2-ethoxyethenyl)-1-[(4-methylphenyl)sulfonyl]-,
(E)-
There total 1 articles about 1H-Indole, 4-bromo-3-(2-ethoxyethenyl)-1-[(4-methylphenyl)sulfonyl]-,
(E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
zirconocene dichloride; tetrakis(triphenylphosphine)nickel(0);
Yield given. Multistep reaction;
1.) benzene, RT, 2 h, 2.) THF, RT, 48 h;
DOI:10.1021/jo00391a027
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) BBr3*SMe2, 2.) 1 M aq. NaHCO3 / 1.) CH2Cl2, RT, 5 min, 2.) CH2Cl2, RT, 2.5 h
2: 92 percent / Pd(OAc)2, (o-tolyl)3P, Et3N / acetonitrile / 5 h / 100 °C
3: 56 percent / p-toluenesulfonic acid / acetonitrile / 4 h / 90 °C
With
palladium diacetate; boron tribromide-dimethyl sulfide complex; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; tris-(o-tolyl)phosphine;
In
acetonitrile;
DOI:10.1021/jo00391a027
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) BBr3*SMe2, 2.) 1 M aq. NaHCO3 / 1.) CH2Cl2, RT, 5 min, 2.) CH2Cl2, RT, 2.5 h
2: 66 percent / molecular sieves, O-methylhydroxylamine hydrochloride / pyridine / 1 h / Ambient temperature
With
molecular sieve; boron tribromide-dimethyl sulfide complex; N-methoxylamine hydrochloride; sodium hydrogencarbonate;
In
pyridine;
DOI:10.1021/jo00391a027
