1H-Indole, 4-bromo-3-(2,2-diethoxyethyl)-1-[(4-methylphenyl)sulfonyl]-

Base Information

Chemical Name:1H-Indole, 4-bromo-3-(2,2-diethoxyethyl)-1-[(4-methylphenyl)sulfonyl]-
CAS No.:108948-24-9
Molecular Formula:C21H24BrNO4S
Molecular Weight:466.396
Hs Code.:
Mol file:108948-24-9.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indole, 4-bromo-3-(2,2-diethoxyethyl)-1-[(4-methylphenyl)sulfonyl]-

Chemical Property:

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Technology Process of 1H-Indole, 4-bromo-3-(2,2-diethoxyethyl)-1-[(4-methylphenyl)sulfonyl]-

There total 2 articles about 1H-Indole, 4-bromo-3-(2,2-diethoxyethyl)-1-[(4-methylphenyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90481-83-7
4-bromo-3-iodo-1-tosyl-1H-indole

: 108948-24-9
4-bromo-3-(2,2-diethoxyethyl)-1-tosylindole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) dicyclopentadienylzirconium chloride, 2.) Ni(PPh₃)4 / 1.) benzene, RT, 2 h, 2.) THF, RT, 48 h

2: 1.) BBr₃*SMe₂, 2.) 1 M aq. NaHCO₃ / 1.) CH₂Cl₂, RT, 5 min, 2.) CH₂Cl₂, RT, 2.5 h

With zirconocene dichloride; boron tribromide-dimethyl sulfide complex; tetrakis(triphenylphosphine)nickel⁽⁰⁾; sodium hydrogencarbonate;
DOI:10.1021/jo00391a027

Reference yield:

: 64-17-5
ethanol

: 108948-23-8
4-bromo-3-(2-ethoxyethen-1-yl)-1-tosylindole

: 108948-24-9
4-bromo-3-(2,2-diethoxyethyl)-1-tosylindole

Guidance literature:: With boron tribromide-dimethyl sulfide complex; sodium hydrogencarbonate; Yield given. Multistep reaction; 1.) CH₂Cl₂, RT, 5 min, 2.) CH₂Cl₂, RT, 2.5 h;
DOI:10.1021/jo00391a027

Reference yield: 92.0%

: 115-18-4
2-methyl-3-buten-2-ol

: 108948-24-9
4-bromo-3-(2,2-diethoxyethyl)-1-tosylindole

: 108948-27-2
3-(2,2-diethoxyethyl)-4-(3-hydroxy-3-methyl-1-buten-1-yl)-1-tosylindole

Guidance literature:: With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In acetonitrile; at 100 ℃; for 5h;
DOI:10.1021/jo00391a027