Ethyl (S)-1-Boc-b-oxo-2-Pyrrolidinepropanoate

Base Information

• Chemical Name: Ethyl (S)-1-Boc-b-oxo-2-Pyrrolidinepropanoate
• CAS No.: 109180-95-2
• Molecular Formula: C₁₄H₂₃NO₅
• Molecular Weight: 285.34
• Mol file: 109180-95-2.mol

Synonyms:

Chemical Property of Ethyl (S)-1-Boc-b-oxo-2-Pyrrolidinepropanoate

Chemical Property:

• Boiling Point: 369.9±32.0 °C(Predicted)
• PKA: 10.33±0.20(Predicted)
• Density: 1.135±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(S)-1-Boc-2-(3-ethoxy-3-oxopropanoyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl (S)-1-Boc-b-oxo-2-Pyrrolidinepropanoate

There total 10 articles about Ethyl (S)-1-Boc-b-oxo-2-Pyrrolidinepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl (2S)-2-[(2,2-dimethyl-4,6-oxo-1,3-dioxan-5-yl)carbonyl]-1-pyrrolidinecarboxylate (603998-95-4) + ethanol (64-17-5) → (S)-tert-butyl 2-(3-ethoxy-3-oxopropanoyl)pyrrolidine-1-carboxylate (109180-95-2,108310-01-6)

Guidance literature:

for 3h; Heating / reflux;

Reference yield: 80.0%

diazoacetic acid ethyl ester (623-73-4) + Boc-L-Pro-H (69610-41-9,117625-90-8) → (S)-tert-butyl 2-(3-ethoxy-3-oxopropanoyl)pyrrolidine-1-carboxylate (109180-95-2,108310-01-6)

Guidance literature:

With tin(ll) chloride; In dichloromethane;

DOI:10.1021/ol403290h

Reference yield: 66.0%

ethyl potassium malonate (6148-64-7) + (S) tert-butyl 2-(1H-imidazole-1-carbonyl)pyrrolidine-1-carboxylate (115655-70-4) → (S)-tert-butyl 2-(3-ethoxy-3-oxopropanoyl)pyrrolidine-1-carboxylate (109180-95-2,108310-01-6)

Guidance literature:

ethyl potassium malonate; With magnesium chloride; In tetrahydrofuran; at 50 ℃; for 6h; Inert atmosphere;

(S) tert-butyl 2-(1H-imidazole-1-carbonyl)pyrrolidine-1-carboxylate; In tetrahydrofuran; at 20 ℃; for 20.3333h; Inert atmosphere;

upstream raw materials:

ethyl lithioacetate

Boc-L-Pro-H

(S)-N-(tert-butoxycarbonyl)proline methyl ester

tert-butyl (2S)-2-[(2,2-dimethyl-4,6-oxo-1,3-dioxan-5-yl)carbonyl]-1-pyrrolidinecarboxylate

Downstream raw materials:

{4-[(1Z)-3-[(2S)-1-(tert-butoxycarbonyl)pyrrolidinyl]-2-(ethoxycarbonyl)-3-oxo-1-propenyl]phenyl}acetic acid

C₃₆H₄₁F₃N₂O₈

4-[2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidinyl]-3,5-bis(ethoxycarbonyl)-6-(4-methylpentyl)-1,4-dihydro-4-pyridinyl]benzoic acid

4-[2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidinyl]-3,5-bis(ethoxycarbonyl)-6-(3,3,3-trifluoropropyl)-1,4-dihydro-4-pyridinyl]benzoic acid

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