2,5-Pyrrolidinedione, 3-[(4-methylphenyl)thio]-1-phenyl-

Base Information

• Chemical Name: 2,5-Pyrrolidinedione, 3-[(4-methylphenyl)thio]-1-phenyl-
• CAS No.: 109448-23-9
• Molecular Formula: C17H15NO2S
• Molecular Weight: 297.378
• DSSTox Substance ID: DTXSID10385673
• Mol file: 109448-23-9.mol

Synonyms:109448-23-9;2,5-Pyrrolidinedione, 3-[(4-methylphenyl)thio]-1-phenyl-;1-Phenyl-3-p-tolylsulfanyl-pyrrolidine-2,5-dione;Cambridge id 5321570;Oprea1_382656;Oprea1_686258;DTXSID10385673;STK748174;AKOS000731224;AKOS021984191;AB00080638-01;SR-01000399028;SR-01000399028-1;3-[(4-methylphenyl)sulfanyl]-1-phenylpyrrolidine-2,5-dione

Chemical Property of 2,5-Pyrrolidinedione, 3-[(4-methylphenyl)thio]-1-phenyl-

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 297.08234989
• Heavy Atom Count: 21
• Complexity: 398

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)SC2CC(=O)N(C2=O)C3=CC=CC=C3

Technology Process of 2,5-Pyrrolidinedione, 3-[(4-methylphenyl)thio]-1-phenyl-

There total 6 articles about 2,5-Pyrrolidinedione, 3-[(4-methylphenyl)thio]-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-phenyl-maleimide (941-69-5) + para-thiocresol (106-45-6) → 3-[(4-methylphenyl)thio]-1-phenyl-pyrrolidine-2,5-dione (109448-23-9)

Guidance literature:

With triethylamine; In acetonitrile; at 80 ℃; for 3h; Solvent; Temperature; Reagent/catalyst;

DOI:10.1055/s-0037-1609585

Reference yield: 55.0%

1-pyrrolidinecarboxaldehyde (3760-54-1) + N-phenyl-maleimide (941-69-5) + para-thiocresol (106-45-6) → 3-[(4-methylphenyl)thio]-1-phenyl-pyrrolidine-2,5-dione (109448-23-9) + 1-phenyl-3-(pyrrolidin-1-yl)-pyrrolidine-2,5-dione (116659-69-9)

Guidance literature:

With copper(l) iodide; tetrafluoroboric acid; at 120 ℃; Mechanism; Inert atmosphere;

DOI:10.1055/s-0037-1610536

Reference yield: 41.0%

pyrrolidine (123-75-1) + N-phenyl-maleimide (941-69-5) + para-thiocresol (106-45-6) → 3-[(4-methylphenyl)thio]-1-phenyl-pyrrolidine-2,5-dione (109448-23-9) + 1-phenyl-3-(pyrrolidin-1-yl)-pyrrolidine-2,5-dione (116659-69-9)

Guidance literature:

With copper(l) iodide; In N,N-dimethyl acetamide; at 120 ℃; for 6h; Inert atmosphere;

DOI:10.1002/adsc.201700955

upstream raw materials:

N-phenyl-maleimide

para-thiocresol

pyrrolidine

1-pyrrolidinecarboxaldehyde

Downstream raw materials:

3-[(4-methylphenyl)thio]-1-phenyl-1H-pyrrole-2,5-dione

1-phenyl-3-(pyrrolidin-1-yl)-1H-pyrrole-2,5-dione

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