Benzenepropanol, 4-(phenylmethoxy)-, acetate

Base Information

• Chemical Name: Benzenepropanol, 4-(phenylmethoxy)-, acetate
• CAS No.: 110128-42-2
• Molecular Formula: C18H20O3
• Molecular Weight: 284.355
• Mol file: 110128-42-2.mol

Synonyms:

Chemical Property of Benzenepropanol, 4-(phenylmethoxy)-, acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanol, 4-(phenylmethoxy)-, acetate

There total 5 articles about Benzenepropanol, 4-(phenylmethoxy)-, acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-(4-acetoxyphenyl)propyl acetate (25823-43-2) + benzyl bromide (100-39-0) → 3-(4'-benzyloxyphenyl)propyl acetate (110128-42-2)

Guidance literature:

With sodium methylate; In N,N-dimethyl-formamide; for 0.5h; Ambient temperature;

DOI:10.1055/s-1997-3267

Reference yield:

3-(4-hydroxyphenyl)propionic acid methyl ester (5597-50-2) → 3-(4'-benzyloxyphenyl)propyl acetate (110128-42-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / KOH / ethanol / 5 h / Heating

2: 56 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 1 h / Heating

3: 75 percent / pyridine / benzene / 2 h / Ambient temperature

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; ethanol; benzene;

Reference yield:

p-Coumaric Acid (7400-08-0,50940-26-6) → 3-(4'-benzyloxyphenyl)propyl acetate (110128-42-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 100 percent / H₂ / PtO₂ / methanol / 760 Torr / Ambient temperature

2: 65 percent / H⁺

3: 78 percent / KOH / ethanol / 5 h / Heating

4: 56 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 1 h / Heating

5: 75 percent / pyridine / benzene / 2 h / Ambient temperature

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; hydrogen; hydrogen cation; platinum(IV) oxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; benzene;

upstream raw materials:

3-(4-acetoxyphenyl)propyl acetate

benzyl bromide

p-Coumaric Acid

4-hydroxyphenylpropionic acid

Downstream raw materials:

3-(4'-hydroxyphenyl)-1-propyl acetate

Refernces

• 1、 Krawczyk, Andrzej R.,Lipkowska, Ewa,Wrobel, Jerzy T.. "A Study on Horseradish Peroxidase-mediated Coupling of Phenolesters, Directed to Synthesis of Lythraceae Alkaloids". . p. 115 - 122. Retrieved 2007/10/02.