Edronax

Base Information

Chemical Name:Edronax
CAS No.:93851-87-7
Molecular Formula:CH₄O₃S*C₁₉H₂₃NO₃
Molecular Weight:409.503
Hs Code.:
DSSTox Substance ID:DTXSID50917492
ChEMBL ID:CHEMBL2146087
Mol file:93851-87-7.mol

Synonyms:2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate;reboxetine;reboxetine mesylate;Vestra

Suppliers and Price of Edronax

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Reboxetine mesylate 95+%
1g
$ 1647.00

Matrix Scientific
Reboxetine mesylate 95+%
250mg
$ 742.00

Total 2 raw suppliers

Chemical Property of Edronax

Chemical Property:

Boiling Point:434.3oC at 760 mmHg
Flash Point:185.2oC
PSA：102.47000
LogP:4.10740
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:409.15590875
Heavy Atom Count:28
Complexity:425

Purity/Quality:

≥99% ^*data from raw suppliers

Reboxetine mesylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=CC=CC=C1OC(C2CNCCO2)C3=CC=CC=C3.CS(=O)(=O)O
Recent EU Clinical Trials:Crossover, Double-blind, Phase 2 Study of a Fixed Dose Combination of Reboxetine\\Oxybutynin (AD128) Versus Placebo in Obstructive Sleep Apnea (RebOx)

Technology Process of Edronax

There total 19 articles about Edronax which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-chloro-N-[3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]acetamide

: 93851-87-7,98769-82-5,98769-84-7,98819-77-3,105017-39-8,141425-90-3
Reboxetine mesylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol

2: methanesulfonic acid / acetone

With methanesulfonic acid; potassium tert-butylate; In isopropyl alcohol; acetone; tert-butyl alcohol;
DOI:10.1039/c1gc15921f

Reference yield:

: 93853-04-4,98769-75-6
(2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate

: 93851-87-7,98769-82-5,98769-84-7,98819-77-3,105017-39-8,141425-90-3
Reboxetine mesylate

Guidance literature:: Multi-step reaction with 3 steps

1: carbonic acid dimethyl ester / ethanol

2: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol

3: methanesulfonic acid / acetone

With methanesulfonic acid; potassium tert-butylate; carbonic acid dimethyl ester; In ethanol; isopropyl alcohol; acetone; tert-butyl alcohol;
DOI:10.1039/c1gc15921f

Reference yield:

: 98769-72-3,98819-72-8
(2RS,3RS)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide

: 93851-87-7,98769-82-5,98769-84-7,98819-77-3,105017-39-8,141425-90-3
Reboxetine mesylate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; ammonia / isopropyl alcohol

2: carbonic acid dimethyl ester / ethanol

3: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol

4: methanesulfonic acid / acetone

With methanol; methanesulfonic acid; potassium tert-butylate; ammonia; carbonic acid dimethyl ester; In ethanol; isopropyl alcohol; acetone; tert-butyl alcohol;
DOI:10.1039/c1gc15921f