2-Propenoic acid, 3-[4-(acetyloxy)-3,5-dimethoxyphenyl]-, ethyl ester

Base Information

• Chemical Name: 2-Propenoic acid, 3-[4-(acetyloxy)-3,5-dimethoxyphenyl]-, ethyl ester
• CAS No.: 110233-74-4
• Molecular Formula: C15H18O6
• Molecular Weight: 294.304
• Mol file: 110233-74-4.mol

Synonyms:Ethylsinapatacetat;4-Acetoxy-3,5-dimethoxy-trans-zimtsaeure-aethylester;ethyl-(4'-acetoxy-3',5'-dimethoxyphenyl)-prop-2-enoate;2-Propenoic acid,3-[4-(acetyloxy)-3,5-dimethoxyphenyl]-,ethyl ester;4-acetoxy-3,5-dimethoxy-trans-cinnamic acid ethyl ester;

Chemical Property of 2-Propenoic acid, 3-[4-(acetyloxy)-3,5-dimethoxyphenyl]-, ethyl ester

Chemical Property:

• PSA: 71.06000
• LogP: 2.20540

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-[4-(acetyloxy)-3,5-dimethoxyphenyl]-, ethyl ester

There total 7 articles about 2-Propenoic acid, 3-[4-(acetyloxy)-3,5-dimethoxyphenyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-4-acetoxy-3,5-dimethoxycinnamic acid (90985-68-5,113158-15-9) → ethyl-(4'-acetoxy-3',5'-dimethoxyphenyl)-prop-2-enoate (110233-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / Heating

2: 1.25 h / Ambient temperature

With thionyl chloride;

Reference yield:

syringic aldehyde (134-96-3) → ethyl-(4'-acetoxy-3',5'-dimethoxyphenyl)-prop-2-enoate (110233-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine; pyridine

2: pyridine

With piperidine; pyridine;

Reference yield:

O-acetylsyringic acid (6318-20-3) → ethyl-(4'-acetoxy-3',5'-dimethoxyphenyl)-prop-2-enoate (110233-74-4)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; SOCl₂

2: palladium/BaSO₄; xylene / Hydrogenation

3: pyridine; aniline; piperidine

With piperidine; pyridine; Pd-BaSO₄; thionyl chloride; aniline; xylene;

upstream raw materials:

ethanol

4-acetoxy-3,5-dimethoxycinnamic acid chloride

hydrogen ethyl malonate

4-acetoxy-3,5-dimethoxybenzaldehyde

Downstream raw materials:

dihydrosinapic acid

3-(3,5-dimethoxy-4-hydroxyphenyl)propionic acid methyl ester

trans-3,5-dimethoxy-4-hydroxycinnamic acid

3-<2-Brom-3,5-dimethoxy-4-acetoxy-phenyl>-propen-(2)-saeure-aethylester