Technology Process of Stannane, trimethyl[2-methyl-1-(phenylmethoxy)propyl]-
There total 1 articles about Stannane, trimethyl[2-methyl-1-(phenylmethoxy)propyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
acetyl chloride;
In
dichloromethane;
under argon; acetal (11.1 mmol) was dissolved in CH2Cl2; treated with 10 ml acetyl chloride at room temp. for 2 h; volatile materials removed (vacuo); dissoln. in THF; addition to Me3SnLi-soln. cooled to -78 °C (1 min); stirring 15 min;; poured into NH4Cl-soln. and petroleum ether; organic layer was sepd., washed (brine); dried (Na2SO4); filtered; concd.; chromy. (silica gel; ethyl acetate/petroleum ether 3:97);;
DOI:10.1021/ja00211a024
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran;
at -78 ℃;
for 0.0333333h;
DOI:10.1021/ja00211a024
- Guidance literature:
-
With
cyclohexanone;
In
tetrahydrofuran;
under argon; treatment of tin-compound in THF at -78 °C with LiBu; stirring 2 min; quenching with cyclohexanone;; poured into NH4Cl-soln. and petroleum ether; shaked 1 min; org. layer separated, washed (brine), dried (Na2SO4), filtered, concd. (vacuo); chromd. (silica gel; ethyl acetate/ petroleum ether 10:90); identical with substance produced otherwise;;
DOI:10.1021/ja00211a024
