3-[2-(3,4-Dimethoxyphenyl)-7-methoxybenzofuran-5-yl]-1-propanol

Base Information

• Chemical Name: 3-[2-(3,4-Dimethoxyphenyl)-7-methoxybenzofuran-5-yl]-1-propanol
• CAS No.: 17375-66-5
• Molecular Formula: C20H22O5
• Molecular Weight: 342.39
• Mol file: 17375-66-5.mol

Synonyms:Homoegonol;

Chemical Property of 3-[2-(3,4-Dimethoxyphenyl)-7-methoxybenzofuran-5-yl]-1-propanol

Chemical Property:

• Vapor Pressure: 4.34E-11mmHg at 25°C
• Boiling Point: 506.7°C at 760 mmHg
• Flash Point: 260.2°C
• PSA: 61.06000
• Density: 1.178g/cm³
• LogP: 4.05050

Purity/Quality:

97% ^*data from raw suppliers

Homoegonol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An analog of Egonol. A new benzofuran from the seeds of Styrax officinalis with antibacterial and antifungal activity.

Technology Process of 3-[2-(3,4-Dimethoxyphenyl)-7-methoxybenzofuran-5-yl]-1-propanol

There total 34 articles about 3-[2-(3,4-Dimethoxyphenyl)-7-methoxybenzofuran-5-yl]-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-5-yl]propyl acetate (17375-67-6) → 5-(3''-hydroxypropyl)-7-methoxy-2-(3',4'-dimethoxyphenyl)benzofuran (17375-66-5)

Guidance literature:

With water; sodium hydroxide; In ethanol; Reflux;

DOI:10.1055/s-0029-1217129

Reference yield: 87.5%

(5-(2-methoxycarbonyl)ethyl)-7-methoxy-2-(3,4-dimethoxyphenyl)benzofuran → 5-(3''-hydroxypropyl)-7-methoxy-2-(3',4'-dimethoxyphenyl)benzofuran (17375-66-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃;

Reference yield: 83.0%

5-allyl-2-(3,4-dimethoxyphenyl)-7-methoxybenzofuran (210229-40-6) → 5-(3''-hydroxypropyl)-7-methoxy-2-(3',4'-dimethoxyphenyl)benzofuran (17375-66-5)

Guidance literature:

5-allyl-2-(3,4-dimethoxyphenyl)-7-methoxybenzofuran; With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 25 ℃; for 2h; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2.16667h;

DOI:10.1055/s-0037-1610169

upstream raw materials:

5-allyl-2-(3,4-dimethoxyphenyl)-7-methoxybenzofuran

5-allyl-2-hydroxy-3-methoxybenzaldehyde

2-allyloxy-3-methoxy-benzaldehyde

4-allyl-2-(hydroxymethyl)-6-methoxyphenol

Downstream raw materials:

3-[2-(3,4-dimethoxyphenyl)-7-methoxy-1-benzofuran-5-yl]propyl acetate