Ethyl 2-chloro-6-fluorophenylacetate

Base Information

• Chemical Name: Ethyl 2-chloro-6-fluorophenylacetate
• CAS No.: 214262-85-8
• Molecular Formula: C₁₀H₁₀ClFO₂
• Molecular Weight: 216.64
• Hs Code.: 2916399090
• DSSTox Substance ID: DTXSID70369797
• Wikidata: Q72473611
• Mol file: 214262-85-8.mol

Synonyms:Ethyl 2-chloro-6-fluorophenylacetate;214262-85-8;ethyl 2-(2-chloro-6-fluorophenyl)acetate;Ethyl 2-chloro-6-fluorophenyl acetate;MFCD00800606;(2-Chloro-6-fluorophenyl)acetic acid ethyl ester;Ethyl (2-chloro-6-fluorophenyl)acetate;SCHEMBL5252336;DTXSID70369797;CEWCLHPMDWPDNQ-UHFFFAOYSA-N;R-Tetrahydropapaverinehydrochloride;BBL102918;STL556727;AKOS005254590;AS-62722;SY043354;CS-0061617;E1038;FT-0643967;2-Chloro-6-fluorophenylacetic Acid Ethyl Ester;A23086

Chemical Property of Ethyl 2-chloro-6-fluorophenylacetate

Chemical Property:

• Appearance/Colour: clear colorless to pale yellow liquid
• Vapor Pressure: 0.0171mmHg at 25°C
• Refractive Index: 1.4975-1.4995
• Boiling Point: 254.6 ºC at 760 mmHg
• Flash Point: 96.4 ºC
• PSA: 26.30000
• Density: 1.238 g/cm³
• LogP: 2.58470
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 216.0353354
• Heavy Atom Count: 14
• Complexity: 199

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 2-Chloro-6-fluorophenylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CC1=C(C=CC=C1Cl)F

Technology Process of Ethyl 2-chloro-6-fluorophenylacetate

There total 1 articles about Ethyl 2-chloro-6-fluorophenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + 2-chloro-6-fluoro-phenylacetic acid (37777-76-7) → ethyl 2-(2-chloro-6-fluorophenyl)acetate (214262-85-8)

Guidance literature:

With sulfuric acid; Reflux; Inert atmosphere;

DOI:10.1021/ja1048847

Reference yield: 19.0%

ethyl 2-(2-chloro-6-fluorophenyl)acetate (214262-85-8) + 6-chloro-4-ethylamino-pyridine-3-carbaldehyde (959163-01-0) → 7-chloro-3-(2-chloro-6-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one (1588423-99-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

ethyl 2-(2-chloro-6-fluorophenyl)acetate (214262-85-8) + formic acid ethyl ester (109-94-4) → ethyl 2-(2-chloro-6-fluorophenyl)-3-hydroxyacrylate (1242653-53-7)

Guidance literature:

With sodium hydride; In mineral oil; at 20 ℃; for 16h;

upstream raw materials:

ethanol

2-chloro-6-fluoro-phenylacetic acid

Downstream raw materials:

7-chloro-3-(2-chloro-6-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

ethyl 2-(2-chloro-6-fluorophenyl)-3-hydroxyacrylate