2-Pyrrolidineacetic acid Methyl ester

Base Information

• Chemical Name: 2-Pyrrolidineacetic acid Methyl ester
• CAS No.: 111704-98-4
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.186
• Mol file: 111704-98-4.mol

Synonyms:methyl 2-pyrrolidin-2-ylethanoate;methyl 2-pyrrolidylacetate;2-Pyrrolidineacetic acid,methyl ester;methyl 2-(pyrrolidin-2-yl)acetate;methyl pyrrolidin-2-ylacetate;pyrrolidin-2-yl-acetic acid methyl ester;

Chemical Property of 2-Pyrrolidineacetic acid Methyl ester

Chemical Property:

• Boiling Point: 190.2±13.0 °C(Predicted)
• PKA: 9.70±0.10(Predicted)
• PSA: 38.33000
• Density: 1.006±0.06 g/cm3(Predicted)
• LogP: 0.63030
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99.90% ^*data from raw suppliers

Pyrrolidin-2-yl-aceticacidmethylester 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl (±)-Pyrrolidine-2-acetate is usedful for asymmetric synthesis of β-amino acids.

Technology Process of 2-Pyrrolidineacetic acid Methyl ester

There total 10 articles about 2-Pyrrolidineacetic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2-pyrrolidineacetic acid hydrochloride (71985-79-0,439918-59-9,53912-85-9) → 2-pyrrolidineacetic acid methyl ester (111704-98-4)

Guidance literature:

With thionyl chloride; at 0 ℃; for 16h; Heating / reflux;

Reference yield: 95.0%

2-methoxycarbonylmethylpyrrolidine-1-carboxylic acid tert-butyl ester (813433-68-0) → 2-pyrrolidineacetic acid methyl ester (111704-98-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield: 87.2%

benzyl 2-(2-methoxy-2-oxo-ethyl)pyrrolidine-1-carboxylate (56633-72-8,61350-63-8) → 2-pyrrolidineacetic acid methyl ester (111704-98-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 25 ℃; for 2h; under 775.743 Torr;

upstream raw materials:

methanol

2-pyrrolidineacetic acid hydrochloride

2-methoxycarbonylmethylpyrrolidine-1-carboxylic acid tert-butyl ester

rac-Pro-OH

Downstream raw materials:

methyl 2-(1-(3,4-dichlorophenylsulfonyl)pyrrolidin-2-yl)acetate

7-benzylperhydropyrrolo<1,2-a><1,6>naphthyridin-5-one

7-benzoyl-1,2,3,3a,4,5,6,7,8,9-decahydropyrrolo<1,2-a><1,6>naphthyridin-5-one

1,2,3,3a,4,5,6,7,8,9-decahydro-7-benzylpyrrolo<1,2-a><1,6>naphthyridin-5-one

Refernces

• 1、 -. "TRICYCLIC FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF p97 COMPLEX". . . Retrieved 2017/09/29.
• 2、 -. "Substituted Sulfonamide Compounds". Page/Page column 41. . Retrieved 2009/01/24.