Propanamide, 3-[[2-hydroxy-3-[2-(methylsulfonyl)phenoxy]propyl](phenylmethyl)amino]- N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-

Base Information

• Chemical Name: Propanamide, 3-[[2-hydroxy-3-[2-(methylsulfonyl)phenoxy]propyl](phenylmethyl)amino]- N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-
• CAS No.: 111822-66-3
• Molecular Formula: C₃₁H₃₆N₄O₆S
• Molecular Weight: 592.716
• Mol file: 111822-66-3.mol

Synonyms:

Chemical Property of Propanamide, 3-[[2-hydroxy-3-[2-(methylsulfonyl)phenoxy]propyl](phenylmethyl)amino]- N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanamide, 3-[[2-hydroxy-3-[2-(methylsulfonyl)phenoxy]propyl](phenylmethyl)amino]- N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-

There total 4 articles about Propanamide, 3-[[2-hydroxy-3-[2-(methylsulfonyl)phenoxy]propyl](phenylmethyl)amino]- N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxyphenyl methyl sulfone (27489-33-4) → 3-{Benzyl-[2-hydroxy-3-(2-methanesulfonyl-phenoxy)-propyl]-amino}-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide (111822-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / K₂CO₃ / butan-2-one / 17 h / Heating

2: propan-1-ol / Heating

With potassium carbonate; In propan-1-ol; butanone;

DOI:10.1021/jm00397a013

Reference yield:

6-<4-(3-bromopropionamido)phenyl>-5-methyl-4,5-dihydro-3(2H)-pyridazinone (111794-34-4) → 3-{Benzyl-[2-hydroxy-3-(2-methanesulfonyl-phenoxy)-propyl]-amino}-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide (111822-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / propan-1-ol / 6 h / Heating

2: propan-1-ol / Heating

In propan-1-ol;

DOI:10.1021/jm00397a013

Reference yield:

6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone (36725-28-7) → 3-{Benzyl-[2-hydroxy-3-(2-methanesulfonyl-phenoxy)-propyl]-amino}-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide (111822-66-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / acetonitrile / 3 h / Heating

2: 81 percent / propan-1-ol / 6 h / Heating

3: propan-1-ol / Heating

In propan-1-ol; acetonitrile;

DOI:10.1021/jm00397a013

upstream raw materials:

1-<2-(methylsulfonyl)phenoxy>-2,3-epoxypropane

6-<4-<3-(benzylamino)propionamido>phenyl>-5-methyl-4,5-dihydro-3(2H)-pyridazinone hydrobromide

2-hydroxyphenyl methyl sulfone

6-<4-(3-bromopropionamido)phenyl>-5-methyl-4,5-dihydro-3(2H)-pyridazinone

Downstream raw materials:

3-[2-Hydroxy-3-(2-methanesulfonyl-phenoxy)-propylamino]-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide