3-[2-Hydroxy-3-(2-methanesulfonyl-phenoxy)-propylamino]-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide

Base Information

• Chemical Name: 3-[2-Hydroxy-3-(2-methanesulfonyl-phenoxy)-propylamino]-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide
• CAS No.: 111794-58-2
• Molecular Formula: C₂₄H₃₀N₄O₆S
• Molecular Weight: 502.591
• Mol file: 111794-58-2.mol

Synonyms:3-[2-Hydroxy-3-(2-methanesulfonyl-phenoxy)-propylamino]-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide

Chemical Property of 3-[2-Hydroxy-3-(2-methanesulfonyl-phenoxy)-propylamino]-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-Hydroxy-3-(2-methanesulfonyl-phenoxy)-propylamino]-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide

There total 6 articles about 3-[2-Hydroxy-3-(2-methanesulfonyl-phenoxy)-propylamino]-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxyphenyl methyl sulfone (27489-33-4) → 3-[2-Hydroxy-3-(2-methanesulfonyl-phenoxy)-propylamino]-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide (111794-58-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / K₂CO₃ / butan-2-one / 17 h / Heating

2: propan-1-ol / Heating

3: H₂ / Pd/C

With hydrogen; potassium carbonate; palladium on activated charcoal; In propan-1-ol; butanone;

DOI:10.1021/jm00397a013

Reference yield:

1-<2-(methylsulfonyl)phenoxy>-2,3-epoxypropane (58048-49-0) → 3-[2-Hydroxy-3-(2-methanesulfonyl-phenoxy)-propylamino]-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide (111794-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: propan-1-ol / Heating

2: H₂ / Pd/C

With hydrogen; palladium on activated charcoal; In propan-1-ol;

DOI:10.1021/jm00397a013

Reference yield:

6-<4-<3-(benzylamino)propionamido>phenyl>-5-methyl-4,5-dihydro-3(2H)-pyridazinone hydrobromide (111794-37-7) → 3-[2-Hydroxy-3-(2-methanesulfonyl-phenoxy)-propylamino]-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide (111794-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: propan-1-ol / Heating

2: H₂ / Pd/C

With hydrogen; palladium on activated charcoal; In propan-1-ol;

DOI:10.1021/jm00397a013

upstream raw materials:

3-{Benzyl-[2-hydroxy-3-(2-methanesulfonyl-phenoxy)-propyl]-amino}-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide

2-hydroxyphenyl methyl sulfone

1-<2-(methylsulfonyl)phenoxy>-2,3-epoxypropane

6-<4-<3-(benzylamino)propionamido>phenyl>-5-methyl-4,5-dihydro-3(2H)-pyridazinone hydrobromide