N-(3-Chloro-4-hydroxyphenyl)acetamide

Base Information

Chemical Name:N-(3-Chloro-4-hydroxyphenyl)acetamide
CAS No.:3964-54-3
Molecular Formula:C8H8ClNO2
Molecular Weight:185.61
Hs Code.:2924299090
European Community (EC) Number:223-570-4
UNII:E11430J0W2
DSSTox Substance ID:DTXSID70192744
Nikkaji Number:J217.794C
Wikidata:Q27276726
Mol file:3964-54-3.mol

Synonyms:N-(3-Chloro-4-hydroxyphenyl)acetamide;3964-54-3;3-Chloro-4-hydroxyacetanilide;4-Acetylamino-2-chlorophenol;Acetamide, N-(3-chloro-4-hydroxyphenyl)-;2-Chloro-4-acetamidophenol;3'-Chloro-4'-hydroxyacetanilide;UNII-E11430J0W2;4-ACETAMIDO-2-CHLOROPHENOL;EINECS 223-570-4;MFCD01318123;E11430J0W2;N-(3-Chloro-4-hydroxyphenyl)acetamide (3-Chloro-4-hydroxyacetanilide);N-(3-chloro-4-hydroxy-phenyl)acetamide;chloro-4-acetamidophenol;SCHEMBL5674663;DTXSID70192744;BCP20088;2-CHLORO-4-ACETYLAMINOPHENOL;AKOS005206798;CS-W022899;FS-3097;SY101186;ACETANILIDE, 3'-CHLORO-4'-HYDROXY-;AM20040376;FT-0615404;PARACETAMOL IMPURITY C [EP IMPURITY];A824668;Q27276726

Suppliers and Price of N-(3-Chloro-4-hydroxyphenyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AHH
3-Chloro-4-hydroxyacetanilide 97%
25g
$ 515.00

AK Scientific
N-(3-Chloro-4-hydroxyphenyl)acetamide
25g
$ 590.00

AK Scientific
N-(3-Chloro-4-hydroxyphenyl)acetamide
1g
$ 112.00

American Custom Chemicals Corporation
3'-CHLORO-4'-HYDROXY ACETANILIDE 95.00%
1G
$ 175.35

Apolloscientific
3-Chloro-4-hydroxyacetanilide 98%
5g
$ 290.00

Apolloscientific
3-Chloro-4-hydroxyacetanilide 98%
1g
$ 145.00

Apolloscientific
3-Chloro-4-hydroxyacetanilide 98%
10g
$ 435.00

Biosynth Carbosynth
3-Chloro-4-hydroxyacetanilide
5 g
$ 150.00

Biosynth Carbosynth
3-Chloro-4-hydroxyacetanilide
1 g
$ 62.50

Biosynth Carbosynth
3-Chloro-4-hydroxyacetanilide
2 g
$ 100.00

Total 37 raw suppliers

Chemical Property of N-(3-Chloro-4-hydroxyphenyl)acetamide

Chemical Property:

Vapor Pressure:2.6E-06mmHg at 25°C
Melting Point:143-144°C
Refractive Index:1.63
Boiling Point:379.9 °C at 760 mmHg
PKA:8.44±0.18(Predicted)
Flash Point:183.5 °C
PSA：49.33000
Density:1.396 g/cm³
LogP:2.07700
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:185.0243562
Heavy Atom Count:12
Complexity:174

Purity/Quality:

99%, ^*data from raw suppliers

3-Chloro-4-hydroxyacetanilide 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.;
Hazard Codes:R36/37/38:Irritating to eyes, respiratory system and skin.;
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1=CC(=C(C=C1)O)Cl
Uses Paracetamol (Acetaminophen -A161220) impurity.

Technology Process of N-(3-Chloro-4-hydroxyphenyl)acetamide

There total 20 articles about N-(3-Chloro-4-hydroxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 60-35-5
acetamide

: 3964-52-1
2-chloro 4-aminophenol

: 3964-54-3
3-chloro-4-hydroxyacetanilide

Guidance literature:: acetamide; With thionyl chloride; In diethyl ether;

2-chloro 4-aminophenol; for 0.15h; Heating;

Reference yield: 65.0%

: 50700-49-7
N-acetyl-p-benzoquinoneimine

: 103-90-2,8055-08-1
4-acetaminophenol

: 3964-54-3
3-chloro-4-hydroxyacetanilide

: 106-51-4
p-benzoquinone

Guidance literature:: With potassium chloride; potassium acetate; acetic acid; In water; at 25 ℃; Rate constant; Product distribution; other buffers; effect of pH (3.09 - 7.77);
DOI:10.1021/ja00261a019

Reference yield:

: 99512-61-5
N-(pivaloyloxy)-4-methoxyacetanilide

: 103-90-2,8055-08-1
4-acetaminophenol

: 3964-54-3
3-chloro-4-hydroxyacetanilide

: 50700-49-7
N-acetyl-p-benzoquinoneimine

: 51-66-1
4-methoxyacetanilide

: 106-51-4
p-benzoquinone

Guidance literature:: With dipotassium hydrogenphosphate; potassium dihydrogenphosphate; potassium chloride; In water; at 25 ℃; Rate constant; Product distribution; Mechanism; various buffers; effect of pH (3.09 - 7.82);
DOI:10.1021/ja00261a019