PHENOXYACETIC ACID N-HYDROXYSUCCINIMIDE ESTER

Base Information

• Chemical Name: PHENOXYACETIC ACID N-HYDROXYSUCCINIMIDE ESTER
• CAS No.: 38678-58-9
• Molecular Formula: C12H11NO5
• Molecular Weight: 249.22
• Hs Code.: 2925190090
• Mol file: 38678-58-9.mol

Synonyms:Phenoxyacetoxysuccinimide;phenoxyacetic acid N-hydroxysuccinimide ester;PhO-CH2CO-OSu;Succinimidyl phenoxyacetate;N-Hydroxysuccinimid-phenoxyacetylester;1-(2-phenoxyacetoxy)pyrrolidine-2,5-dione;N-<(phenoxyacetyl)oxy>succinimide;

Chemical Property of PHENOXYACETIC ACID N-HYDROXYSUCCINIMIDE ESTER

Chemical Property:

• Vapor Pressure: 2.25E-06mmHg at 25°C
• Boiling Point: 392.7°C at 760 mmHg
• Flash Point: 191.3°C
• PSA: 72.91000
• Density: 1.38g/cm³
• LogP: 0.61050
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Phenoxyacetic acid N-hydroxysuccinimide ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of PHENOXYACETIC ACID N-HYDROXYSUCCINIMIDE ESTER

There total 4 articles about PHENOXYACETIC ACID N-HYDROXYSUCCINIMIDE ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 2-phenoxyacetic acid (122-59-8) → N-<(phenoxyacetyl)oxy>succinimide (38678-58-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate;

DOI:10.1021/jm00157a005

Reference yield:

2-phenoxyacetic acid (122-59-8) → N-<(phenoxyacetyl)oxy>succinimide (38678-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C

2: triethylamine / dichloromethane; N,N-dimethyl-formamide / 2.25 h

With oxalyl dichloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm401709b

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Phenoxyacetyl chloride (701-99-5) → N-<(phenoxyacetyl)oxy>succinimide (38678-58-9)

Guidance literature:

With triethylamine; In dichloromethane; N,N-dimethyl-formamide; for 2.25h;

DOI:10.1021/jm401709b

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

2-phenoxyacetic acid

Phenoxyacetyl chloride

Downstream raw materials:

PhO-CH₂CO-Ser-Ala-OBzl

PhOCH₂CO-Arg(NO₂)-Ala-OBzl

PhO-CH₂CO-D-Arg(NO₂)-D-Ala-OBzl

PhO-CH₂CO-Tyr-Ala-OBzl

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