Chemical Property of Piperlonguminine
Chemical Property:
- Vapor Pressure:2.94E-09mmHg at 25°C
- Boiling Point:476.9°C at 760 mmHg
- Flash Point:242.2°C
- PSA：47.56000
- Density:1.136g/cm3
- LogP:3.14780
- Solubility.:≤3mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
- XLogP3:3.8
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:5
- Exact Mass:273.13649347
- Heavy Atom Count:20
- Complexity:376
- Purity/Quality:
-
99%, *data from raw suppliers
Piperlonguminine ≥98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC(C)CNC(=O)C=CC=CC1=CC2=C(C=C1)OCO2
- Isomeric SMILES:CC(C)CNC(=O)/C=C/C=C/C1=CC2=C(C=C1)OCO2
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Description
This amide alkaloid also occurs in the roots of Piper longum and yields colourless
needles from EtOH. The ultraviolet spectrum exhibits absorption maxima at 245,256, 307 and 340 mil. The side chain is doubly unsaturated and on catalytic
hydrogenation, the base furnishes the tetrahydro derivative, m.p. 66°C. Piperlonguminine is an alkaloid amide from species of the genus Piper, a plant used in traditional medicine that demonstrates antifungal, anticancer, antihyperlipidemic, and anti-inflammatory properties. Piperlonguminine (3-12.5 μM) has been shown to dose dependently decrease expression of amyloid precursor protein and amyloid-β peptide in human neuroblastoma cells, suggesting it may have implication in treating Alzheimer’s disease.
