ethyl 3-(1H-indol-3-yl)propanoate

Base Information

• Chemical Name: ethyl 3-(1H-indol-3-yl)propanoate
• CAS No.: 40641-03-0
• Molecular Formula: C13H15 N O2
• Molecular Weight: 217.268
• Mol file: 40641-03-0.mol

Synonyms:Indole-3-propionicacid, ethyl ester (7CI); Ethyl 3-(1H-indol-3-yl)propanoate; Ethylindole-3-propionate; NSC 14694; NSC 61455

Chemical Property of ethyl 3-(1H-indol-3-yl)propanoate

Chemical Property:

• Vapor Pressure: 1.33E-05mmHg at 25°C
• Boiling Point: 367.8°Cat760mmHg
• Flash Point: 176.3°C
• Density: 1.157g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 3-(1H-indol-3-yl)propanoate

There total 9 articles about ethyl 3-(1H-indol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Indole-3-propionic acid (830-96-6) + ethanol (64-17-5) → ethyl 3-(indol-3-yl)propanoate (40641-03-0)

Guidance literature:

With sulfuric acid; In water; at 0 ℃; Reflux;

DOI:10.1016/j.phytochem.2010.10.002

Reference yield: 91.0%

indole (120-72-9) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 3-(indol-3-yl)propanoate (40641-03-0)

Guidance literature:

bismuth oxide perchlorate; In acetonitrile; for 0.75h; ultrasonic irradiation;

DOI:10.3987/COM-06-10697

Reference yield: 63.0%

ethyl 3-(1H-indol-3-yl)acrylate (15181-86-9) → ethyl 3-(indol-3-yl)propanoate (40641-03-0)

Guidance literature:

With ammonia; lithium perchlorate; In acetonitrile; at 20 ℃; Electrochemical reaction;

DOI:10.1002/anie.201813464

upstream raw materials:

Indole-3-propionic acid

ethanol

indole

ethyl acrylate

Downstream raw materials:

3-{1-[(tert-butoxy)carbonyl]-1H-indol-3-yl}propionic acid

1H-indole-3-propanol

5-(2-(1H-indol-3-yl)ethyl)-2-(4-(3,5,6-trichloropyridin-2-yloxy))-1,3,4-oxadiazole

5-(3-(1H-indol-3-yl)ethyl)-2-(3-phenoxyphenyl)-1,3,4-oxadiazole

Refernces

• 1、 Smith,Sogn. "-". . p. 822. Retrieved 1945.
• 2、 Gavara, Laurent,Legru, Alice,Verdirosa, Federica,Sevaille, Laurent,Nauton, Lionel,Corsica, Giuseppina,Mercuri, Paola Sandra,Sannio, Filomena,Feller, Georges,Coulon, Rémi,De Luca, Filomena,Cerboni, Giulia,Tanfoni, Silvia,Chelini, Giulia,Galleni, Moreno,Docquier, Jean-Denis,Hernandez, Jean-Fran?ois. "4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors". supporting information. . Retrieved 2021/06/15.
• 3、 -. "SUBSTITUTED TETRAHYDROPYRANOINDOLES, DERIVATIVES THEREOF, AND THEIR METHODS OF SYNTHESIS AND USE". Paragraph 0160; 0161. . Retrieved 2021/01/25.