Technology Process of 5-Isoxazoleacetic acid, 3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-
There total 7 articles about 5-Isoxazoleacetic acid, 3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran;
Yield given;
Ambient temperature;
DOI:10.1248/cpb.36.3142
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 64 percent / hydroxylamine hidrochloride, KOH / tetrahydrofuran; ethanol / Ambient temperature
2: n-BuLi / hexane; tetrahydrofuran / 1 h / Ambient temperature
3: concentrated H2SO4 / tetrahydrofuran; hexane / 1 h / Heating
4: p-toluenesulfonic acid monohydrate / Ambient temperature
5: n-BuLi / hexane; tetrahydrofuran / 1 h / -70 °C
6: concentrated HCl / tetrahydrofuran / Ambient temperature
With
hydrogenchloride; potassium hydroxide; n-butyllithium; sulfuric acid; hydroxylamine hydrochloride; toluene-4-sulfonic acid;
In
tetrahydrofuran; ethanol; hexane;
DOI:10.1248/cpb.36.3142
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 80 percent / p-toluenesulfonic acid monohydrate / 6 h / Ambient temperature
2: 64 percent / hydroxylamine hidrochloride, KOH / tetrahydrofuran; ethanol / Ambient temperature
3: n-BuLi / hexane; tetrahydrofuran / 1 h / Ambient temperature
4: concentrated H2SO4 / tetrahydrofuran; hexane / 1 h / Heating
5: p-toluenesulfonic acid monohydrate / Ambient temperature
6: n-BuLi / hexane; tetrahydrofuran / 1 h / -70 °C
7: concentrated HCl / tetrahydrofuran / Ambient temperature
With
hydrogenchloride; potassium hydroxide; n-butyllithium; sulfuric acid; hydroxylamine hydrochloride; toluene-4-sulfonic acid;
In
tetrahydrofuran; ethanol; hexane;
DOI:10.1248/cpb.36.3142