1-(2-Fluoro-6-methoxyphenyl)piperazine

Base Information

Chemical Name:1-(2-Fluoro-6-methoxyphenyl)piperazine
CAS No.:113028-78-7
Molecular Formula:C11H15FN2O
Molecular Weight:0.00000
Hs Code.:
European Community (EC) Number:888-362-3
ChEMBL ID:CHEMBL4541010
Mol file:113028-78-7.mol

Synonyms:1-(2-fluoro-6-methoxyphenyl)piperazine;113028-78-7;SCHEMBL9523382;CHEMBL4541010;FNYYIKRCDSATNB-UHFFFAOYSA-N;MFCD11872779;AKOS023546018;AB90455;CS-0235153;EN300-153356

Suppliers and Price of 1-(2-Fluoro-6-methoxyphenyl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(2-Fluoro-6-methoxyphenyl)piperazine
5mg
$ 65.00

Matrix Scientific
1-(2-Fluoro-6-methoxyphenyl)piperazine 95%
5g
$ 1841.00

Matrix Scientific
1-(2-Fluoro-6-methoxyphenyl)piperazine 95%
1g
$ 916.00

AK Scientific
1-(2-Fluoro-6-methoxyphenyl)piperazine
250mg
$ 730.00

ACHEMBLOCK
1-(2-fluoro-6-methoxyphenyl)piperazine 95%
5G
$ 3510.00

Total 6 raw suppliers

Chemical Property of 1-(2-Fluoro-6-methoxyphenyl)piperazine

Chemical Property:

Vapor Pressure:0.000467mmHg at 25°C
Boiling Point:314.4±42.0 °C(Predicted)
PKA:8.80±0.10(Predicted)
PSA：0.00000
Density:1.130±0.06 g/cm3(Predicted)
LogP:0.00000
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:210.11684127
Heavy Atom Count:15
Complexity:197

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Fluoro-6-methoxyphenyl)piperazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C(=CC=C1)F)N2CCNCC2

Technology Process of 1-(2-Fluoro-6-methoxyphenyl)piperazine

There total 3 articles about 1-(2-Fluoro-6-methoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 446-61-7
2-fluoro-6-methoxyphenylamine

: 43204-63-3
bis(2-bromoethyl)amine hydrobromide

: 113028-78-7
1-(2-fluoro-6-methoxyphenyl)piperazine

Guidance literature:: With potassium hydroxide; sodium hydroxide; In water;

Reference yield:

: C₁₆H₂₃FN₂O₃

: 113028-78-7
1-(2-fluoro-6-methoxyphenyl)piperazine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1016/j.bmcl.2016.02.050

Reference yield:

: 446-59-3
2‐bromo‐1‐fluoro‐3‐methoxybenzene

: 113028-78-7
1-(2-fluoro-6-methoxyphenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; XPhos; sodium t-butanolate / toluene / 90 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; palladium diacetate; sodium t-butanolate; XPhos; In 1,4-dioxane; toluene; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2016.02.050