29683-77-0

Basic information

• Product Name: 2-(CHLOROACETYL)THIOPHENE
• Synonyms: 2-(CHLOROACETYL)THIOPHENE;2-CHLORO-1-THIOPHEN-2-YL-ETHANONE;2-Chloro-1-Thiophene-2-yl-Ethanone;2-Chloro-1-(thien-2-yl)ethan-1-one;2-Chloro-1-(2-thienyl)ethanone;ChloroMethyl 2-Thienyl Ketone;2-(Chloroacetyl)thiophene (>85%);2-Chloro-1-thien-2-ylethanone
• CAS NO: 29683-77-0
• Molecular Formula: C₆H₅ClOS
• Molecular Weight: 160.62
• Product Categories: Sulfur & Selenium Compounds
• Mol File: 29683-77-0.mol
• Article Data: 20

Chemical Properties

• Melting Point: 45°C
• Boiling Point: 265.1 °C at 760 mmHg
• Flash Point: 114.1 °C
• Appearance: White Solid
• Density: 1.318 g/cm³
• Vapor Pressure: 0.00936mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-(CHLOROACETYL)THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROACETYL)THIOPHENE(29683-77-0)
• EPA Substance Registry System: 2-(CHLOROACETYL)THIOPHENE(29683-77-0)

Safety Data

• Hazardous Substances Data: 29683-77-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

2-(Chloroacetyl)thiophene (>85%) (cas# 29683-77-0) is a compound useful in organic synthesis.

InChI:InChI=1/C6H5ClOS/c7-4-5(8)6-2-1-3-9-6/h1-3H,4H2

Upstream product

• 527-72-0 2-thiophenylcarboxylic acid 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 72676-21-2 2-diazo-1-(thiophen-2-yl)ethanone 
• 84370-27-4 1-chloro-1-(2-thienyl)ethylene 
• 62889-07-0 trimethyl((1-(thiophen-2-yl)vinyl)oxy)silane 
• 88-15-3 2-Acetylthiophene 
• 188290-36-0 thiophene 
• 79-04-9 chloroacetyl chloride 
• 556025-93-5 [[1-(2-thienyl)ethenyl]oxy]tri-isopropylsilane 
• 556025-94-6 [[2-chloro-1-(2-thienyl)ethenyl]oxy]tri-isopropylsilane 
• 929618-13-3 (E)-2-(2-chloro-1-ethoxyethenyl)thiophene 

Downstream Products

• 4045-03-8 2-(thiophen-2-yl)imidazo[1,2-a]pyridine 
• 109644-97-5 dimethyl-(2-oxo-2-[2]thienyl-ethyl)-phenacyl-ammonium; chloride 
• 41444-32-0 2-ethylsulfanyl-1-thiophen-2-yl-ethanone 
• 1285718-93-5 C₁₃H₉FO₂S 
• 1285718-92-4 C₁₃H₉ClO₂S 
• 1285718-90-2 C₁₃H₉ClO₂S 
• 40327-67-1 trans-(2R,3S)-epoxy-3-phenyl-1-(2-thienyl)propan-1-one 
• 40327-67-1 (-)-2(R),3(S)-epoxy-3-phenyl-1-(2-thienyl)propan-1-one 
• 1285718-91-3 C₁₃H₉ClO₂S 
• 1285718-94-6 (2R,3S)-2,3-epoxy-1-(2-thienyl)-3-(2-tolyl)-propan-1-one 
• 1918-77-0 Thiophene-2-acetic acid 
• 1446308-43-5 (3R)-3-(2-(4-fluorophenyl)-2-(piperidin-1-yl)acetoxy)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride 
• 1446307-77-2 (3R)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-3-(2-phenyl-2-(piperidin-1-yl)acetoxy)-1-azonia-bicyclo[2.2.2]octane 
• 1446307-78-3 (3R)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-3-(2-phenyl-2-(piperidin-1-yl)acetoxy)-1-azonia-bicyclo[2.2.2]octane trifluoroacetate trifluoroacetate anion 

Relevant articles and documents

PREPARATION OF AN α,β-TYPE OF TER- AND SEPTITHIOPHENES

An α,β-type of thiophenes oligomers, 2,3':4',2"-terthiophene and 2,3':4',2'':5'',3''':4''',2'''':5'''',3''''':4''''',2''''''-septithiophene, were synthesized through intramolecular reductive coupling reaction of diketo sulfides with a low-valent titanium reagent.

Iridium-Catalyzed Asymmetric Hydrogenation of Halogenated Ketones for the Efficient Construction of Chiral Halohydrins

Iridium-catalyzed asymmetric hydrogenation of prochiral halogenated ketones was successfully developed to prepare various chiral halohydrins with high reactivities and excellent enantioselectivities under basic reaction condition (up to >99% conversion, 99% yield, >99% ee). Moreover, gram-scale experiment was performed well in the presence of just 0.005 mol% (S/C=20 000) Ir/f-amphox catalyst with 99% yield and >99% ee. (Figure presented.).

The α-chlorination of aryl methyl ketones under aerobic oxidative conditions

The novel reaction system air/ammonium nitrate/iodine/hydrochloric acid [air/NH4NO3(cat.)/I2(cat.)/HCl] is introduced as a simple, safe, cheap, efficient and regioselective mediator for the α-chlorination of aryl, heteroaryl and alkyl methyl ketones under aerobic oxidative conditions. The inventive use of a catalytic amount of iodine enabled the moderate to quantitative, regioselective chlorination of a comprehensive scope of different methyl ketone derivatives including those bearing oxidizable heteroatom (S, N) substituents, some of which possess declared potential biological and pharmaceutical activity. Air oxygen under a slight overpressure plays the role of the terminal oxidant catalytically activated by redox cycles of nitrogen oxides released from the catalytic amount of ammonium nitrate (NH4NO3) under acidic conditions of hydrochloric acid (HCl) and co-catalyzed by elemental iodine (I2), which was found to be essential for the high efficiency of the reaction system.