L-Serine, O-(1,1-dimethylethyl)-N-[N-[N-[O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-yl methoxy)carbonyl]-D-seryl]glycyl]-L-phenylalanyl]-, phenylmethyl ester

Base Information

Chemical Name:L-Serine, O-(1,1-dimethylethyl)-N-[N-[N-[O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-yl methoxy)carbonyl]-D-seryl]glycyl]-L-phenylalanyl]-, phenylmethyl ester
CAS No.:113247-79-3
Molecular Formula:C₄₇H₅₆N₄O₉
Molecular Weight:820.983
Hs Code.:
Mol file:113247-79-3.mol

L-Serine,
O-(1,1-dimethylethyl)-N-[N-[N-[O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-yl
methoxy)carbonyl]-D-seryl]glycyl]-L-phenylalanyl]-, phenylmethyl ester

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Chemical Property of L-Serine, O-(1,1-dimethylethyl)-N-[N-[N-[O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-yl methoxy)carbonyl]-D-seryl]glycyl]-L-phenylalanyl]-, phenylmethyl ester

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Technology Process of L-Serine, O-(1,1-dimethylethyl)-N-[N-[N-[O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-yl methoxy)carbonyl]-D-seryl]glycyl]-L-phenylalanyl]-, phenylmethyl ester

There total 15 articles about L-Serine, O-(1,1-dimethylethyl)-N-[N-[N-[O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-yl methoxy)carbonyl]-D-seryl]glycyl]-L-phenylalanyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 113247-78-2
L-phenylalanine-O-t-butyl-L-serine benzyl ester

: [(R)-3-tert-Butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-acetic acid benzotriazol-1-yl ester

: 113247-79-3
N-fluorenylmethoxycarbonyl-O-t-butyl-D-seryl-glycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 0 deg C --> room temp., 2 h;

Reference yield:

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 113247-79-3
N-fluorenylmethoxycarbonyl-O-t-butyl-D-seryl-glycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: DCCI / tetrahydrofuran / 0 °C

2: N,N-di-isopropylethylamine / tetrahydrofuran / 0 deg C --> room temp., 2 h

3: DCCI / tetrahydrofuran / 0 °C

4: N,N-di-isopropylethylamine / tetrahydrofuran / 0 deg C --> room temp., 2 h

5: 93 percent / H₂ / Pd/C / ethanol; ethyl acetate / 1 h

6: DCCI / tetrahydrofuran / 0 °C

7: N,N-diisopropylethylamine / tetrahydrofuran / 0 deg C --> room temp., 2 h

With hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate;

Reference yield:

: 113247-73-7
N-fluorenylmethoxycarbonyl-O-t-butyl-D-serylglycyne benzyl ester

: 113247-79-3
N-fluorenylmethoxycarbonyl-O-t-butyl-D-seryl-glycyl-L-phenylalanyl-O-t-butyl-L-serine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DCCI / tetrahydrofuran / 0 °C

2: N,N-di-isopropylethylamine / tetrahydrofuran / 0 deg C --> room temp., 2 h

3: 93 percent / H₂ / Pd/C / ethanol; ethyl acetate / 1 h

4: DCCI / tetrahydrofuran / 0 °C

5: N,N-diisopropylethylamine / tetrahydrofuran / 0 deg C --> room temp., 2 h

With hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate;