Propionanilide, N-(7-phenyl-2-alpha,3,4,6,7-beta,11b-alpha-hexahydro-1H-benzo(a)quinolizin-2-yl)-

Base Information

Chemical Name:Propionanilide, N-(7-phenyl-2-alpha,3,4,6,7-beta,11b-alpha-hexahydro-1H-benzo(a)quinolizin-2-yl)-
CAS No.:75688-92-5
Molecular Formula:C₂₈H₃₀N₂O
Molecular Weight:410.559
Hs Code.:
DSSTox Substance ID:DTXSID10997114

Synonyms:75688-92-5;Propionanilide, N-(7-phenyl-2-alpha,3,4,6,7-beta,11b-alpha-hexahydro-1H-benzo(a)quinolizin-2-yl)-;C28-H30-N2-O;75715-65-0;Propionanilide, N-(7-phenyl-2-alpha,3,4,6,7-alpha,11b-alpha-hexahydro-1H-benzo(a)quinolizin-2-yl)-;C28H30N2O;DTXSID10997114;LS-124448;LS-124449;N-Phenyl-N-(7-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl)propanamide

Suppliers and Price of Propionanilide, N-(7-phenyl-2-alpha,3,4,6,7-beta,11b-alpha-hexahydro-1H-benzo(a)quinolizin-2-yl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propionanilide, N-(7-phenyl-2-alpha,3,4,6,7-beta,11b-alpha-hexahydro-1H-benzo(a)quinolizin-2-yl)-

Chemical Property:

Vapor Pressure:1.56E-12mmHg at 25°C
Boiling Point:559.1°Cat760mmHg
Flash Point:228.6°C
Density:1.18g/cm³
XLogP3:5.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:410.235813585
Heavy Atom Count:31
Complexity:594

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=O)N(C1CCN2CC(C3=CC=CC=C3C2C1)C4=CC=CC=C4)C5=CC=CC=C5

Technology Process of Propionanilide, N-(7-phenyl-2-alpha,3,4,6,7-beta,11b-alpha-hexahydro-1H-benzo(a)quinolizin-2-yl)-

There total 6 articles about Propionanilide, N-(7-phenyl-2-alpha,3,4,6,7-beta,11b-alpha-hexahydro-1H-benzo(a)quinolizin-2-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 79-03-8
propionyl chloride

: 75715-67-2,75715-68-3,75715-72-9,75715-73-0,83509-76-6,91549-02-9
Phenyl-((7S,11bS)-7-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl)-amine

: 75688-92-5,75715-64-9,75715-65-0,75715-66-1
N-(2β,7α,11bα)-(1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzo quinolizin-2-yl)-N-phenylpropanamide

: 75688-92-5,75715-64-9,75715-65-0,75715-66-1
N-(2α,7α,11bα)-(1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzo quinolizin-2-yl)-N-phenylpropanamide

Guidance literature:: In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00133a017

Reference yield: 15.0%

: 79-03-8
propionyl chloride

: 75715-67-2,75715-68-3,75715-72-9,75715-73-0,83509-76-6,91549-02-9
Phenyl-((7S,11bS)-7-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl)-amine

: 75688-92-5,75715-64-9,75715-65-0,75715-66-1
N-(2β,7α,11bα)-(1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzo quinolizin-2-yl)-N-phenylpropanamide

: 75688-92-5,75715-64-9,75715-65-0,75715-66-1
N-(2α,7α,11bα)-(1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzo quinolizin-2-yl)-N-phenylpropanamide

Guidance literature:: In dichloromethane; for 16h; Ambient temperature;
DOI:10.1021/jm00133a017

Reference yield:

: 142-04-1,36663-09-9
aniline hydrochloride

: 75688-92-5,75715-64-9,75715-65-0,75715-66-1
N-(2β,7β,11bα)-(1,3,4,6,7,11b-hexahydro-7-phenyl-2H-benzo quinolizin-2-yl)-N-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) p-TsOH, 2.) NaCNBH₃ / 1.) toluene, reflux, 5.25 h, 2.) THF, 0 deg C, 30 min, molecular sieves (Linde 4A)

2: CH₂Cl₂ / 16 h / Ambient temperature

With sodium cyanoborohydride; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1021/jm00133a017