Cyclohexanepropanoic acid, b-hydroxy-, methyl ester, (S)-

Base Information

• Chemical Name: Cyclohexanepropanoic acid, b-hydroxy-, methyl ester, (S)-
• CAS No.: 113309-44-7
• Molecular Formula: C10H18O3
• Molecular Weight: 186.251
• Mol file: 113309-44-7.mol

Synonyms:

Chemical Property of Cyclohexanepropanoic acid, b-hydroxy-, methyl ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanepropanoic acid, b-hydroxy-, methyl ester, (S)-

There total 7 articles about Cyclohexanepropanoic acid, b-hydroxy-, methyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

methanol (67-56-1) + C15H25NO3Se → (3S) methyl 3-hydroxy-3-cyclohexylpropanoate (113309-44-7)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1080/00397910802419706

Reference yield:

methyl 3-cyclohexyl-3-oxopropionate (64670-15-1) → (3S) methyl 3-hydroxy-3-cyclohexylpropanoate (113309-44-7)

Guidance literature:

With (S,S)-Cy-PBE-RuBr₂; hydrogen; In methanol; water; at 35 ℃; for 20h; under 3102.9 Torr;

Reference yield:

methyl 3-cyclohexyl-3-oxopropionate (64670-15-1) → (3S) methyl 3-hydroxy-3-cyclohexylpropanoate (113309-44-7) + (3R) methyl 3-hydroxy-3-cyclohexylpropanoate (142037-74-9)

Guidance literature:

With L-Tartaric acid; hydrogen; sodium bromide; nickel; In tetrahydrofuran; at 60 ℃; for 75h; under 750060 Torr; Title compound not separated from byproducts;

DOI:10.1246/bcsj.75.355

upstream raw materials:

methyl (2S,3R)-3-cyclohexyloxiranecarboxylate

methyl 3-cyclohexyl-3-oxopropionate

ketene t-butyldimethylsilyl methyl acetal

cyclohexanecarbaldehyde

Downstream raw materials:

(S)-1-cyclohexyl-1,3-propanediol

(S)-3-cyclohexyl-1,3-diacetoxypropane

(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-cyclohexyl-2-methoxycarbonyl-ethyl ester