Technology Process of methyl (2S,3R)-3-cyclohexyloxiranecarboxylate
There total 7 articles about methyl (2S,3R)-3-cyclohexyloxiranecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 12 h / 20 °C
2.1: La-(S)-BINOL-Ph3AsO complex; 4 Angstroem molecular sieves; tert-butyl hydroperoxide / toluene; tetrahydrofuran / 4 h / 20 °C
2.2: tetrahydrofuran; toluene / 20 °C
With
tert.-butylhydroperoxide; La-(S)-BINOL-Ph3AsO; 4 A molecular sieve; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2003.06.010
- Guidance literature:
-
1-[(2E)-3-cyclohexyl-1-oxo-2-propenyl]-4-phenyl-1H-imidazole;
With
tert.-butylhydroperoxide; La-(S)-BINOL-Ph3AsO; 4 A molecular sieve;
In
tetrahydrofuran; toluene;
at 20 ℃;
for 4h;
methanol;
In
tetrahydrofuran; toluene;
at 20 ℃;
Title compound not separated from byproducts;
DOI:10.1016/j.tet.2003.06.010
- Guidance literature:
-
Multi-step reaction with 4 steps
1: SOCl2, pyridine / CH2Cl2 / 0 °C
2: RuCl3, NaIO4 / acetonitrile; H2O
3: 1.) LiBr; 2.) 20percent H2SO4 / 1.) THF, r.t., 2h; 2.) Et2O
4: K2CO3 / 4 h / -23 °C
With
pyridine; ruthenium trichloride; sodium periodate; thionyl chloride; sulfuric acid; potassium carbonate; lithium bromide;
In
dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(98)00190-7
