Methyl chromane-2-carboxylate

Base Information

• Chemical Name: Methyl chromane-2-carboxylate
• CAS No.: 113771-58-7
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.214
• Hs Code.: 2932999099
• Mol file: 113771-58-7.mol

Synonyms:chroman-2-carboxylic acid methyl ester;methyl chromane-2-carboxylate;2H-1-Benzopyran-2-carboxylic acid,3,4-dihydro-,methyl ester;methyl chroman-2-carboxylate;(R,S)-chroman-2-carboxylic acid methyl ester;2-methoxycarbonylchroman;

Chemical Property of Methyl chromane-2-carboxylate

Chemical Property:

• PSA: 35.53000
• LogP: 1.55320
• Storage Temp.: 2-8°C

Purity/Quality:

99.90% ^*data from raw suppliers

Methylchroman-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl chromane-2-carboxylate

There total 16 articles about Methyl chromane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + chroman-2-carboxylic acid (51939-71-0) → chroman-2-carboxylic acid methyl ester (66598-81-0,66598-82-1,113771-58-7)

Guidance literature:

With diazomethyl-trimethyl-silane; In diethyl ether; dichloromethane; at 0 ℃; for 1h;

Reference yield: 95.0%

chroman-2-carboxylic acid (51939-71-0) + diazomethyl-trimethyl-silane (18107-18-1) → chroman-2-carboxylic acid methyl ester (66598-81-0,66598-82-1,113771-58-7)

Guidance literature:

In methanol; diethyl ether; dichloromethane; at 0 ℃; for 1h;

Reference yield: 95.0%

methyl 2-diazo-4-(2-hydroxyphenyl)butanoate → chroman-2-carboxylic acid methyl ester (66598-81-0,66598-82-1,113771-58-7)

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; C₂₃H₂₂N₂O₂; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In dichloromethane; at 25 ℃; for 0.0833333h; Reagent/catalyst; enantioselective reaction; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1002/anie.201209455

upstream raw materials:

methanol

chroman-2-carboxylic acid

acide chromone carboxylique-2

2-(phenylmethoxy)benzaldehyde

Downstream raw materials:

chroman-2-ylcarboxamide

3,4-dihydro-2H-1-benzopyran-2-methanol

(2R)-3,4-dihydro-2H-chromen-2-ylmethylamine hydrochloride

(R)-chroman-2-carboxylic acid chloride

Refernces

• 1、 Kitagaki, Shinji,Murata, Shunsuke,Asaoka, Kisaki,Sugisaka, Kenta,Mukai, Chisato,Takenaga, Naoko,Yoshida, Keisuke. "Planar chiral [2.2]paracyclophane-based bisoxazoline ligands: Design, synthesis, and use in cu-catalyzed inter- and intramolecular asymmetric O-H insertion reactions". . p. 1006 - 1014. Retrieved 2018/10/08.
• 2、 -. "NEW SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS". Page/Page column 143. . Retrieved 2014/12/12.