Benzeneacetic acid,5-chloro-2-hydroxy-

Base Information

• Chemical Name: Benzeneacetic acid,5-chloro-2-hydroxy-
• CAS No.: 24161-38-4
• Molecular Formula: C8H7 Cl O3
• Molecular Weight: 186.5924
• Hs Code.: 2918999090
• Mol file: 24161-38-4.mol

Synonyms:Aceticacid, (5-chloro-2-hydroxyphenyl)- (8CI); (5-Chloro-2-hydroxyphenyl)acetic acid;NSC 54854

Chemical Property of Benzeneacetic acid,5-chloro-2-hydroxy-

Chemical Property:

• Vapor Pressure: 8.66E-06mmHg at 25°C
• Boiling Point: 359.3°Cat760mmHg
• Flash Point: 171.1°C
• PSA: 57.53000
• Density: 1.466g/cm³
• LogP: 1.67270

Purity/Quality:

99% ^*data from raw suppliers

2-(5-chloro-2-hydroxyphenyl)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid,5-chloro-2-hydroxy-

There total 8 articles about Benzeneacetic acid,5-chloro-2-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(5-chloro-2-methoxy-phenyl)-acetic acid (7569-62-2) → 5-chloro-2-hydroxyphenylacetic acid (24161-38-4)

Guidance literature:

With hydrogen bromide; for 24h; Heating;

DOI:10.1002/bscb.19800890607

Reference yield:

4-chloromethoxybenzene (623-12-1) → 5-chloro-2-hydroxyphenylacetic acid (24161-38-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 67 percent / zinc chloride, hydrogen chloride / 2 h / 70 °C

2: 93 percent / ethanol; H₂O / 6 h / Heating

3: 70 percent / aq. sulfuric acid / 2 h / Heating

4: 64 percent / 48 percent hydrobromic acid / 24 h / Heating

With hydrogenchloride; sulfuric acid; hydrogen bromide; zinc(II) chloride; In ethanol; water;

DOI:10.1002/bscb.19800890607

Reference yield:

4-chloro-2-chloromethyl-1-methoxy-benzene (7035-11-2) → 5-chloro-2-hydroxyphenylacetic acid (24161-38-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / ethanol; H₂O / 6 h / Heating

2: 70 percent / aq. sulfuric acid / 2 h / Heating

3: 64 percent / 48 percent hydrobromic acid / 24 h / Heating

With sulfuric acid; hydrogen bromide; In ethanol; water;

DOI:10.1002/bscb.19800890607

upstream raw materials:

(5-chloro-2-methoxy-phenyl)-acetic acid

ethanol

4-chloromethoxybenzene

4-chloro-2-chloromethyl-1-methoxy-benzene

Downstream raw materials:

(5-Chloro-2-ethoxycarbonylmethoxy-phenyl)-acetic acid ethyl ester

ethyl (5-chloro-2-hydroxyphenyl)acetate

Refernces

• 1、 -. "Methods of using piperazine derivatives". . . Retrieved 2008/06/13.
• 2、 Verhe,De Kimpe,De Buyck,et al.. "Preparation of synthetic rotenoids". . p. 459 - 485. Retrieved 2007/10/02.