Phenol, 2,6-difluoro-, sodium salt

Base Information

• Chemical Name: Phenol, 2,6-difluoro-, sodium salt
• CAS No.: 113981-42-3
• Molecular Formula: C6H4F2O.Na
• Molecular Weight: 152.076
• Mol file: 113981-42-3.mol

Synonyms:

Chemical Property of Phenol, 2,6-difluoro-, sodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 2,6-difluoro-, sodium salt

There total 2 articles about Phenol, 2,6-difluoro-, sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,6-difluorophenol (28177-48-2) → sodium 2,6-difluorophenolate (113981-42-3)

Guidance literature:

With sodium hydroxide; In methanol; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201405060

Reference yield:

2,6-difluorophenyl phenyl sulfate (820220-75-5) → phenyl sulfate sodium salt + sodium 2,6-difluorophenolate (113981-42-3)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 40 ℃; Further Variations:; reagent concentrations; Kinetics;

DOI:10.1021/jo0488309

Reference yield: 97.0%

bi(allylnickel bromide) + sodium 2,6-difluorophenolate (113981-42-3) → [(η3-allyl)(μ-2,6-difluorophenoxide)nickel]2 (154789-03-4)

Guidance literature:

In diethyl ether; byproducts: NaBr; reaction under inert gas: mixture of starting materials in ether is stirred for 1 h at room temp.; filtn., removal of solvent, dissolving in CH2Cl2, filtn., removal of solvent, recrystn. from CH2Cl2/pentane, vac. drying at room temp., elem. anal.;

DOI:10.1021/om00017a073

upstream raw materials:

2,6-difluorophenol

2,6-difluorophenyl phenyl sulfate

Downstream raw materials:

1-(2,6-difluorophenoxy)-4-nitrobenzene

[(η3-allyl)(μ-2,6-difluorophenoxide)nickel]2

3-fluorocatechol

Refernces

• 1、 Serrano-Plana, Joan,Garcia-Bosch, Isaac,Miyake, Ryosuke,Costas, Miquel,Company, Anna. "Selective ortho-hydroxylation-defluorination of 2-fluorophenolates with a Bis(μ-oxo)dicopper(III) species". supporting information. p. 9608 - 9612. Retrieved 2014/10/15.