Morpholine, 4-(1,3-diphenyl-2-propynyl)-

Base Information

• Chemical Name: Morpholine, 4-(1,3-diphenyl-2-propynyl)-
• CAS No.: 114460-92-3
• Molecular Formula: C19H19NO
• Molecular Weight: 277.366
• DSSTox Substance ID: DTXSID30396221
• Nikkaji Number: J1.087.303G
• Mol file: 114460-92-3.mol

Synonyms:4-(1,3-diphenylprop-2-ynyl)morpholine;Morpholine, 4-(1,3-diphenyl-2-propynyl)-;114460-92-3;SCHEMBL12418788;DTXSID30396221;1,3-Diphenyl-3-morpholino-1-propyne

Chemical Property of Morpholine, 4-(1,3-diphenyl-2-propynyl)-

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 277.146664230
• Heavy Atom Count: 21
• Complexity: 362

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(C#CC2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Morpholine, 4-(1,3-diphenyl-2-propynyl)-

There total 15 articles about Morpholine, 4-(1,3-diphenyl-2-propynyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + benzaldehyde (100-52-7) + phenylacetylene (536-74-3) → 1,3-diphenyl-3-morpholino-1-propyne (114460-92-3)

Guidance literature:

With Cu(OH)_x-Fe₃O₄; at 120 ℃; for 3h; neat (no solvent);

DOI:10.1039/b917923b

Reference yield: 96.0%

1-(4-morpholinomethyl)-1H-benzotriazole (5472-71-9) + C20H20Al(1-)*Na(1+) → 1,3-diphenyl-3-morpholino-1-propyne (114460-92-3)

Guidance literature:

In toluene; for 3h; Ambient temperature;

DOI:10.1021/jo9814750

Reference yield: 92.0%

morpholine (110-91-8,99108-56-2) + benzaldehyde (100-52-7) + phenylpropyolic acid (637-44-5) → 1,3-diphenyl-3-morpholino-1-propyne (114460-92-3)

Guidance literature:

In neat (no solvent); at 110 ℃; for 3.5h; Reagent/catalyst; Solvent; Temperature; Catalytic behavior; Green chemistry;

DOI:10.1016/j.tetlet.2016.08.066

upstream raw materials:

4,4'-(phenylmethylene)bismorpholine

phenylacetylene

1-morpholino[(phenyl)methyl]benzotriazole

1-(4-morpholinomethyl)-1H-benzotriazole

Downstream raw materials:

2,3,5-triphenylfuran