Morpholine, 4-[1-(4-methoxyphenyl)-3-phenyl-2-propynyl]-

Base Information

• Chemical Name: Morpholine, 4-[1-(4-methoxyphenyl)-3-phenyl-2-propynyl]-
• CAS No.: 114460-94-5
• Molecular Formula: C20H21NO2
• Molecular Weight: 307.392
• DSSTox Substance ID: DTXSID90396343
• Nikkaji Number: J2.637.339E
• Mol file: 114460-94-5.mol

Synonyms:Enamine_001537;114460-94-5;Morpholine, 4-[1-(4-methoxyphenyl)-3-phenyl-2-propynyl]-;Oprea1_358461;DTXSID90396343;HMS1398F19;STK793010;AKOS005228982;SR-01000218144;4-[alpha-(Phenylethynyl)-p-methoxybenzyl]morpholine;SR-01000218144-1;Z56803500;4-[1-(4-methoxyphenyl)-3-phenylprop-2-yn-1-yl]morpholine;4-(1-(4-methoxyphenyl)-3-phenylprop-2-yn-1-yl) morpholine

Chemical Property of Morpholine, 4-[1-(4-methoxyphenyl)-3-phenyl-2-propynyl]-

Chemical Property:

• PSA: 21.70000
• LogP: 3.05810
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 307.157228913
• Heavy Atom Count: 23
• Complexity: 404

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C#CC2=CC=CC=C2)N3CCOCC3

Technology Process of Morpholine, 4-[1-(4-methoxyphenyl)-3-phenyl-2-propynyl]-

There total 7 articles about Morpholine, 4-[1-(4-methoxyphenyl)-3-phenyl-2-propynyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + 4-methoxy-benzaldehyde (123-11-5) + phenylacetylene (536-74-3) → 4-(1-(4-methoxyphenyl)-3-phenylprop-2-ynyl)morpholine (114460-94-5)

Guidance literature:

With copper(II) supported on graphene quantum dots modified nickel ferrite nanoparticles; at 100 ℃; for 0.75h; Green chemistry;

DOI:10.1007/s10562-020-03400-y

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + 4-methoxy-benzaldehyde (123-11-5) + 1-Phenyl-2-(trimethylsilyl)acetylene (2170-06-1) → 4-(1-(4-methoxyphenyl)-3-phenylprop-2-ynyl)morpholine (114460-94-5)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); copper(l) chloride; In acetonitrile; at 100 ℃; for 2h;

DOI:10.1055/S-2008-1077790

Reference yield: 94.0%

morpholine (110-91-8,99108-56-2) + 4-methoxy-benzaldehyde (123-11-5) + phenylpropyolic acid (637-44-5) → 4-(1-(4-methoxyphenyl)-3-phenylprop-2-ynyl)morpholine (114460-94-5)

Guidance literature:

In neat (no solvent); at 110 ℃; Green chemistry;

DOI:10.1016/j.tetlet.2016.08.066

upstream raw materials:

4-(dimorpholinomethyl)-1-methoxybenzene

phenylacetylene

morpholine

4-methoxy-benzaldehyde

Refernces

• 1、 Bhatte, Kushal D.,Sawant, Dinesh N.,Deshmukh, Krishna M.,Bhanage, Bhalchandra M.. "Nanosize Co3O4 as a novel, robust, efficient and recyclable catalyst for A3-coupling reaction of propargylamines". . p. 114 - 119. Retrieved 2011.
• 2、 Movahed, Siyavash Kazemi,Shariatipour, Monire,Dabiri, Minoo. "Gold nanoparticles decorated on a graphene-periodic mesoporous silica sandwich nanocomposite as a highly efficient and recyclable heterogeneous catalyst for catalytic applications". . p. 33423 - 33431. Retrieved 2015.
• 3、 Baharfar, Robabeh,Hosseinzadeh, Rahman,Peiman, Sahar. "CuI NPs immobilized on a ternary hybrid system of magnetic nanosilica, PAMAM dendrimer and trypsin, as an efficient catalyst for A3?coupling reaction". . . Retrieved 2022/01/24.
• 4、 Bagherzade, Azra,Nemati, Firouzeh. "Solvent-free coupling of aldehyde, alkyne, and amine over a versatile catalyst: Ag-functionalized mesoporous S, P-doped g-C3N4". . p. 2917 - 2933. Retrieved 2021/04/19.