7-CHLORO-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE

Base Information

• Chemical Name: 7-CHLORO-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE
• CAS No.: 5177-39-9
• Molecular Formula: C₉H₇ClN₂O₂
• Molecular Weight: 210.62
• Hs Code.: 2933990090
• Mol file: 5177-39-9.mol

Synonyms:7-Chloro-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione;NSC 319999;

Chemical Property of 7-CHLORO-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE

Chemical Property:

• Vapor Pressure: 4.3E-13mmHg at 25°C
• Refractive Index: 1.58
• Boiling Point: 572 °C at 760 mmHg
• Flash Point: 299.7 °C
• PSA: 58.20000
• Density: 1.394 g/cm³
• LogP: 1.48870
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

7-CHLORO-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-2,5-DIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-CHLORO-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE

There total 7 articles about 7-CHLORO-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

5-chloro-1H-benzo[d][1,3]oxazine-2,4-dione (20829-96-3) + glycine (56-40-6,18875-39-3,25718-94-9) → 7-chloro-2,3,5-trihydro-1H,4H-1,4-benzodiazepine-2,5-dione (5177-39-9)

Guidance literature:

In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; acetic acid;

Reference yield: 63.0%

5-Chloroisatoic anhydride (4743-17-3) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → 7-chloro-2,3,5-trihydro-1H,4H-1,4-benzodiazepine-2,5-dione (5177-39-9)

Guidance literature:

With pyridine; at 110 ℃; for 18h;

Reference yield: 54.0%

6-chloro-1,2,3-benzotriazin-4(3H)-one (37429-97-3) + glycine (56-40-6,18875-39-3,25718-94-9) → 7-chloro-2,3,5-trihydro-1H,4H-1,4-benzodiazepine-2,5-dione (5177-39-9)

Guidance literature:

In various solvent(s); at 250 - 260 ℃; for 10h;

DOI:10.1515/HC.2003.9.4.363

upstream raw materials:

6-chloro-1,2,3-benzotriazin-4(3H)-one

glycine

o-Amino-5-chlor-hippursaeureethylester

5-Chloroisatoic anhydride

Downstream raw materials:

7-chloro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

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