cyclohexyl 5-oxoprolinate

Base Information

• Chemical Name: cyclohexyl 5-oxoprolinate
• CAS No.: 31437-47-5
• Molecular Formula: C11H17 N O3
• Molecular Weight: 211.261
• Hs Code.: 2933790090
• Mol file: 31437-47-5.mol

Synonyms:Proline,5-oxo-, cyclohexyl ester, L- (8CI); Cyclohexyl pyroglutamate

Chemical Property of cyclohexyl 5-oxoprolinate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 384.8°Cat760mmHg
• Flash Point: 186.5°C
• PSA: 58.89000
• Density: 1.15g/cm³
• LogP: 1.41680

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cyclohexyl 5-oxoprolinate

There total 1 articles about cyclohexyl 5-oxoprolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

Pyroglutamic acid (149-87-1) + cyclohexanol (108-93-0) → cyclohexyl 5-oxoprolinate (31437-47-5)

Guidance literature:

With calcium carbide; toluene-4-sulfonic acid; In toluene; Heating;

DOI:10.1002/jhet.5570250108

Reference yield: 57.0%

chloro-trimethyl-silane (75-77-4) + cyclohexyl 5-oxoprolinate (31437-47-5) → 5-Oxo-1-trimethylsilanyl-pyrrolidine-2-carboxylic acid cyclohexyl ester (116871-87-5)

Guidance literature:

With triethylamine; In toluene;

DOI:10.1002/jhet.5570250108

Reference yield:

cyclohexyl 5-oxoprolinate (31437-47-5) → 1-(2-Chloro-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid cyclohexyl ester (116872-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / triethylamine / toluene

2: 88 percent / tetrahydrofuran / Heating; overnight

With triethylamine; In tetrahydrofuran; toluene;

DOI:10.1002/jhet.5570250108

upstream raw materials:

Pyroglutamic acid

cyclohexanol

Downstream raw materials:

5-Oxo-1-trimethylsilanyl-pyrrolidine-2-carboxylic acid cyclohexyl ester

1-(2-Chloro-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid cyclohexyl ester

1-(2-Chloro-2-phenyl-acetyl)-5-oxo-pyrrolidine-2-carboxylic acid cyclohexyl ester