3,5-dimethoxy-N-methylaniline

Base Information

• Chemical Name: 3,5-dimethoxy-N-methylaniline
• CAS No.: 118684-17-6
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.208
• DSSTox Substance ID: DTXSID501300385
• Nikkaji Number: J2.651.331F
• Mol file: 118684-17-6.mol

Synonyms:3,5-dimethoxy-N-methylaniline;118684-17-6;3,5-dimethoxy-N-methylBenzenamine;SCHEMBL1547868;DZJRIEASIKLRQK-UHFFFAOYSA-N;DTXSID501300385;AKOS000256417;CS-0301380;EN300-171205

Chemical Property of 3,5-dimethoxy-N-methylaniline

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 167.094628657
• Heavy Atom Count: 12
• Complexity: 118

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNC1=CC(=CC(=C1)OC)OC

Technology Process of 3,5-dimethoxy-N-methylaniline

There total 7 articles about 3,5-dimethoxy-N-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-chloro-3,5-dimethoxybenzene (7051-16-3) + methylamine (74-89-5) → N-(3,5-dimethoxyphenyl)-N-methylamine (118684-17-6)

Guidance literature:

With dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl] [2-(2-aminoethyl)phenyl]palladium(II); sodium t-butanolate; In tetrahydrofuran; tert-butyl alcohol; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja8055358

Reference yield: 90.0%

→ N-(3,5-dimethoxyphenyl)-N-methylamine (118684-17-6)

Guidance literature:

Reference yield: 76.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3.5-dimethoxyaniline (10272-07-8) → N-(3,5-dimethoxyphenyl)-N-methylamine (118684-17-6)

Guidance literature:

formaldehyd; 3.5-dimethoxyaniline; With sodium methylate; In methanol; at 30 ℃; for 5h;

With sodium tetrahydroborate; In methanol; for 15h;

DOI:10.1016/j.bmcl.2008.12.034

upstream raw materials:

3.5-dimethoxyaniline

methyl iodide

1-chloro-3,5-dimethoxybenzene

methylamine

Downstream raw materials:

<<<(3,5-dimethoxyphenyl)methyl>amino>methylene>propanedioic acid diethyl ester

4-(5-Hydroxy-1-methyl-4-oxo-1,4-dihydro-quinolin-7-yloxymethyl)-3-methoxy-benzoic acid

4-(6-Allyl-5-hydroxy-1-methyl-4-oxo-1,4-dihydro-quinolin-7-yloxymethyl)-3-methoxy-benzoic acid

N-methyl-N-(3,5-dimethoxyphenyl)isonicotinamide