3-(2-Chloroactyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

Base Information

Chemical Name:3-(2-Chloroactyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
CAS No.:119670-13-2
Molecular Formula:C7H13Cl2N2O3P
Molecular Weight:275.06900
Hs Code.:
UNII:SD8LX239CL
Mol file:119670-13-2.mol

Synonyms:72578-71-3;2'-Oxo Ifosfamide;Ifosfamide acylate;119670-13-2;3-(2-Chloroactyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide;SD8LX239CL;2-chloro-1-[2-(2-chloroethylamino)-2-oxo-1,3,2lambda5-oxazaphosphinan-3-yl]ethanone;2H-1,3,2-Oxazaphosphorin-2-amine,3-(chloroacetyl)-N-(2-chloroethyl)tetrahydro-, 2-oxide, (R)-;(R)-2-Chloro-1-(2-((2-chloroethyl)amino)-2-oxido-1,3,2-oxazaphosphinan-3-yl)ethanone;2-Chloro-1-(2-((2-chloroethyl)amino)-2-oxido-1,3,2-oxazaphosphinan-3-yl)ethan-1-one;2-Chloro-1-(2-((2-chloroethyl)amino)dihydro-2-oxido-2H-1,3,2-oxazaphosphorin-3(4H)-yl)ethanone;Ethanone, 2-chloro-1-(2-((2-chloroethyl)amino)dihydro-2-oxido-2H-1,3,2-oxazaphosphorin-3(4H)-yl)-;starbld0039856;UNII-SD8LX239CL;Ifosfamide acylation objects;IFOSFAMIDE Compound III;SCHEMBL7593141;AKOS015895964;CS-O-15620;3-(Chloroacetyl)-N-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide;2 inverted exclamation mark -Oxo Ifosfamide;FT-0653131;FT-0673373;A837567;J-004172;2-chloro-1-[2-(2-chloroethylamino)-2-oxo-1,3,2$l^{5}-oxazaphosphorinan-3-yl]ethanone;3-(2-chloroacetyl)-2-[(2-chloroethyl)amino]-1,3,2|E?-oxazaphosphinan-2-one;2-chloranyl-1-[2-(2-chloroethylamino)-2-oxidanylidene-1,3,2$l^{5}-oxazaphosphinan-3-yl]ethanone;Ethanone, 2-chloro-1-[2-[(2-chloroethyl)amino]dihydro-2-oxido-2H-1,3,2-oxazaphosphorin-3(4H)-yl]-;2H-1,3,2-Oxazaphosphorin-2-amine, 3-(chloroacetyl)-N-(2-chloroethyl)tetrahydro-, 2-oxide (9CI);Ifosfamide Impurity G

Suppliers and Price of 3-(2-Chloroactyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2'-OXO IFOSFAMIDE 95.00%
5MG
$ 501.22

Total 10 raw suppliers

Chemical Property of 3-(2-Chloroactyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

Chemical Property:

Boiling Point:355.0±52.0 °C(Predicted)
PKA:-1.29±0.20(Predicted)
PSA：68.45000
Density:1.42±0.1 g/cm3(Predicted)
LogP:1.73940
Storage Temp.:Hygroscopic, -20?C Freezer, Under Inert Atmosphere
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:274.0040847
Heavy Atom Count:15
Complexity:277

Purity/Quality:

99%, ^*data from raw suppliers

2'-OXO IFOSFAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(P(=O)(OC1)NCCCl)C(=O)CCl
Uses Ifosfamide intermediate

Technology Process of 3-(2-Chloroactyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

There total 1 articles about 3-(2-Chloroactyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 870-24-6
2-chloroethanamine hydrochloride

: 79-04-9
chloroacetyl chloride

: 156-87-6
propan-1-ol-3-amine

: 119670-13-2
3-chloroacetyltetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

Guidance literature:: propan-1-ol-3-amine; With 2-methyl-but-2-ene; triethylamine; trichlorophosphate; In chloroform; at -5 - 20 ℃;

2-chloroethanamine hydrochloride; With triethylamine; In chloroform; at 20 ℃; for 1h;

chloroacetyl chloride; In chloroform; at 40 ℃; for 1h;