4-Pentyn-1-ol, 5-[tris(1-methylethyl)silyl]-

Base Information

Chemical Name:4-Pentyn-1-ol, 5-[tris(1-methylethyl)silyl]-
CAS No.:120585-14-0
Molecular Formula:C14H28OSi
Molecular Weight:240.45700
Hs Code.:
Mol file:120585-14-0.mol

Synonyms:5-triisopropylsilanyl-pent-4-yn-1-ol;

Suppliers and Price of 4-Pentyn-1-ol, 5-[tris(1-methylethyl)silyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Pentyn-1-ol, 5-[tris(1-methylethyl)silyl]-

Chemical Property:

PSA：20.23000
LogP:3.98030

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Pentyn-1-ol, 5-[tris(1-methylethyl)silyl]-

There total 2 articles about 4-Pentyn-1-ol, 5-[tris(1-methylethyl)silyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 5390-04-5
pent-1-yn-5-ol

: 13224-84-5
5-trimethylsilanyl-pent-4-yn-1-ol

: 120585-14-0
5-(tri-isopropylsilyl)pent-4-yn-1-ol

Guidance literature:: With n-butyllithium; triisopropylsilyl chloride; Yield given. Multistep reaction. Yields of byproduct given; 1.) hexane, THF, r.t., 1 h, 2.) hexane, 0 deg C, 30 min, r.t., 17 h;

Reference yield:

: 5390-04-5
pent-1-yn-5-ol

: 13154-24-0
triisopropylsilyl chloride

: 13224-84-5
5-trimethylsilanyl-pent-4-yn-1-ol

: 120585-14-0
5-(tri-isopropylsilyl)pent-4-yn-1-ol

Guidance literature:: With n-butyllithium; chloro-trimethyl-silane; Yield given. Multistep reaction. Yields of byproduct given; 1.) hexane, THF, r.t., 1 h, 2.) hexane, 0 deg C, 30 min, r.t., 17 h;

Reference yield:

: 120585-14-0
5-(tri-isopropylsilyl)pent-4-yn-1-ol

: 403696-87-7
2-((E)-(S)-1-Hydroxy-3-methyl-hexa-2,5-dienyl)-4-methoxy-5-((Z)-2-methyl-hept-2-en-6-ynyl)-phenol

Guidance literature:: Multi-step reaction with 10 steps

1.1: 90 percent / Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.5 h / 20 °C

2.1: 2.044 g / tetrahydrofuran / 0.17 h / -20 °C

3.1: zinc; dibromoethane / tetrahydrofuran / 0.83 h / 0 °C

3.2: 98 percent / palladium tetrakis(triphenylphosphine) / tetrahydrofuran / 27 h / 23 °C

4.1: n-butyllithium / diethyl ether; hexane / 0.75 h / -78 °C

4.2: 94 percent / diethyl ether / -78 - 35 °C

5.1: borontribromide / CH₂Cl₂ / 16 h / -78 - 23 °C

6.1: 5.53 g / diisopropylethylamine / CH₂Cl₂ / 0.5 h / 0 °C

7.1: tert-butyllithium / diethyl ether; pentane / 1 h / -78 °C

7.2: ZnBr₂; (1S,2R)-N-methylephedrine; n-butyllithium / diethyl ether; toluene; hexane / 1 h / 0 °C

7.3: 91 percent / toluene; diethyl ether / 1 h / 0 °C

8.1: tetrabutylammonium fluoride / tetrahydrofuran / 0.17 h / 0 °C

9.1: H₂; quinoline / Pd/BaSO₄ / methanol; hexane / 4.67 h / 23 °C / 760.05 Torr

10.1: tetrabutylammonium fluoride / tetrahydrofuran / 0 - 23 °C

10.2: 18 h / 23 °C

With quinoline; n-butyllithium; 1,1-Dibromoethane; tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; boron tribromide; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; zinc; Pd-BaSO₄; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; pentane; 9.1: Lindlar hydrogenation;
DOI:10.1021/ja016585u