4-Chloro-2-methyl-6-nitroquinoline

Base Information

• Chemical Name: 4-Chloro-2-methyl-6-nitroquinoline
• CAS No.: 1207-81-4
• Molecular Formula: C10H7ClN2O2
• Molecular Weight: 222.631
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID10408174
• Wikidata: Q82213553
• Mol file: 1207-81-4.mol

Synonyms:4-Chloro-2-methyl-6-nitroquinoline;1207-81-4;SCHEMBL3763346;DTXSID10408174;JLGPAZQKQYSOTR-UHFFFAOYSA-N;BAA20781;AKOS000267973;SB71929;FT-0710198;EN300-132229;F1901-0064

Chemical Property of 4-Chloro-2-methyl-6-nitroquinoline

Chemical Property:

• Vapor Pressure: 6.54E-05mmHg at 25°C
• PSA: 58.71000
• LogP: 3.62800
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 222.0196052
• Heavy Atom Count: 15
• Complexity: 256

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-2-methyl-6-nitroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C2C=C(C=CC2=N1)[N+](=O)[O-])Cl

Technology Process of 4-Chloro-2-methyl-6-nitroquinoline

There total 9 articles about 4-Chloro-2-methyl-6-nitroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-methyl-6-nitro-1H-quinolin-4-one (112219-43-9) → 4-chloro-2-methyl-6-nitroquinoline (1207-81-4)

Guidance literature:

With trichlorophosphate; for 1h; Reflux;

DOI:10.1016/j.ejmech.2014.06.066

Reference yield: 82.0%

2-methyl-6-nitroquinoline-4-ol (1207-82-5) → 4-chloro-2-methyl-6-nitroquinoline (1207-81-4)

Guidance literature:

With trichlorophosphate; at 180 ℃; for 3h;

DOI:10.2174/1570180812666151016205033

Reference yield:

ammonium hydroxide (1336-21-6) + 2-methyl-6-nitroquinoline-4-ol (1207-82-5) → 4-chloro-2-methyl-6-nitroquinoline (1207-81-4)

Guidance literature:

In trichlorophosphate;

upstream raw materials:

2-methyl-6-nitroquinoline-4-ol

2-methyl-6-nitroquinoline

4-chloro-2-methylquinoline

4-hydroxy-2-methylquinoline

Downstream raw materials:

N-(4-chlorophenyl)-2-methyl-6-nitroquinolin-4-amine

4-amino-2-methyl-6-nitroquinoline

N-(4-amino-2-methylquinolin-6-yl)-2-phenylacetamide