2,4-Quinazolinediamine, 5-(2-phenylethyl)-

Base Information

Chemical Name:2,4-Quinazolinediamine, 5-(2-phenylethyl)-
CAS No.:123242-02-4
Molecular Formula:C16H16N4
Molecular Weight:264.33
Hs Code.:
Mol file:123242-02-4.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4-Quinazolinediamine, 5-(2-phenylethyl)-

Chemical Property:

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Technology Process of 2,4-Quinazolinediamine, 5-(2-phenylethyl)-

There total 10 articles about 2,4-Quinazolinediamine, 5-(2-phenylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 123241-52-1
2-amino-6-(phenylethyl)benzonitrile

: 29671-92-9
chloroformamidine hydrochloride

: 123242-02-4
5-Phenethyl-quinazoline-2,4-diamine

Guidance literature:: In diethylene glycol dimethyl ether; at 130 - 140 ℃; for 3h;
DOI:10.1021/jm00163a067

Reference yield:

: 35213-00-4
2,6-dinitrobenzonitrile

: 123242-02-4
5-Phenethyl-quinazoline-2,4-diamine

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / hydrochloric acid, iron / methanol; dioxane / 0.5 h / Heating

2: 1.) sodium nitrite, sulfuric acid, 2.) potassium iodide, aq. sulfuric acid / 1.) acetic acid, 40 deg C, 30 min, 2.) RT, 60 min

3: 90 percent / iron, concentrated hydrochloric acid / methanol / 0.17 h

4: 88 percent / palladium(II) acetate, tri(2-tolyl)phosphine, copper(I) iodide / various solvent(s) / 1.5 h / Ambient temperature

5: 93 percent / hydrogen / 10percent palladium on charcoal / ethanol / 0.33 h / 760 Torr / Ambient temperature

6: 27 percent / bis-(2-methoxy-ethyl) ether / 3 h / 130 - 140 °C

With hydrogenchloride; copper(l) iodide; sulfuric acid; hydrogen; palladium diacetate; iron; tris-(o-tolyl)phosphine; potassium iodide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; diethylene glycol dimethyl ether;
DOI:10.1021/jm00163a067

Reference yield:

: 63365-23-1
2-amino-6-nitrobenzonitrile

: 123242-02-4
5-Phenethyl-quinazoline-2,4-diamine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) sodium nitrite, sulfuric acid, 2.) potassium iodide, aq. sulfuric acid / 1.) acetic acid, 40 deg C, 30 min, 2.) RT, 60 min

2: 90 percent / iron, concentrated hydrochloric acid / methanol / 0.17 h

3: 88 percent / palladium(II) acetate, tri(2-tolyl)phosphine, copper(I) iodide / various solvent(s) / 1.5 h / Ambient temperature

4: 93 percent / hydrogen / 10percent palladium on charcoal / ethanol / 0.33 h / 760 Torr / Ambient temperature

5: 27 percent / bis-(2-methoxy-ethyl) ether / 3 h / 130 - 140 °C

With hydrogenchloride; copper(l) iodide; sulfuric acid; hydrogen; palladium diacetate; iron; tris-(o-tolyl)phosphine; potassium iodide; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; diethylene glycol dimethyl ether;
DOI:10.1021/jm00163a067