2 4-DIAMINO-5-IODOQUINAZOLINE

Base Information

• Chemical Name: 2 4-DIAMINO-5-IODOQUINAZOLINE
• CAS No.: 119584-76-8
• Molecular Formula: C8H7 I N4
• Molecular Weight: 286.07245
• Hs Code.: 2933998090
• Mol file: 119584-76-8.mol

Synonyms:5-Iodoquinazoline-2,4-diamine

Chemical Property of 2 4-DIAMINO-5-IODOQUINAZOLINE

Chemical Property:

• Vapor Pressure: 3.13E-11mmHg at 25°C
• Boiling Point: 527.9°Cat760mmHg
• Flash Point: 273°C
• PSA: 77.82000
• Density: 2.093g/cm³
• LogP: 2.56120

Purity/Quality:

98%min ^*data from raw suppliers

5-Iodoquinazoline-2,4-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2 4-DIAMINO-5-IODOQUINAZOLINE

There total 9 articles about 2 4-DIAMINO-5-IODOQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

guanidine hydrogen carbonate (124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9) + 2-fluoro-6-iodobenzonitrile (79544-29-9) → 2,4-diamino-5-iodoquinazoline (119584-76-8)

Guidance literature:

In N,N-dimethyl acetamide; at 140 - 142 ℃; for 8h;

Reference yield: 46.0%

2-amino-6-iodobenzonitrile (123241-50-9) + chloroformamidine hydrochloride (29671-92-9) → 2,4-diamino-5-iodoquinazoline (119584-76-8)

Guidance literature:

In diethylene glycol dimethyl ether; at 130 - 140 ℃; for 3h;

DOI:10.1021/jm00163a067

Reference yield:

diguanidine carbonate (593-85-1,90332-86-8,3425-08-9) + 2-fluoro-6-iodobenzonitrile (79544-29-9) → 2,4-diamino-5-iodoquinazoline (119584-76-8)

Guidance literature:

In ISOPROPYLAMIDE; at 165 ℃; for 5h;

upstream raw materials:

2-amino-6-iodobenzonitrile

chloroformamidine hydrochloride

guanidine hydrogen carbonate

2-fluoro-6-iodobenzonitrile

Downstream raw materials:

5-Phenethyl-quinazoline-2,4-diamine

2,4-diaminoquinazoline-5-carbonitrile

Refernces

• 1、 Harris, Neil V.,Smith, Christopher,Bowden, Keith. "Antifolate and Antibacterial Activities of 5-Substituted 2,4-Diaminoquinazolines". . p. 434 - 444. Retrieved 2007/10/02.