1-Piperidinecarboxylic acid, 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbonyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbonyl]-, 1,1-dimethylethyl ester
CAS No.:124443-69-2
Molecular Formula:C25H28FN3O3
Molecular Weight:437.514
Hs Code.:
Mol file:124443-69-2.mol

Synonyms:

Suppliers and Price of 1-Piperidinecarboxylic acid, 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbonyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbonyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbonyl]-, 1,1-dimethylethyl ester

There total 8 articles about 1-Piperidinecarboxylic acid, 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbonyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459-56-3
4-fluorobenzylic alcohol

: 142850-90-6
[1H-benzimidazol-2-yl][1-(t-butyloxycarbonyl)-4-piperidinyl]methanone

: 1972-28-7,218603-74-8
diethylazodicarboxylate

: 124443-69-2
4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbonyl]-1-piperidinecarboxylic acid,1,1-dimethylethyl ester

Guidance literature:: With triphenylphosphine; In tetrahydrofuran;

Reference yield:

: 7462-86-4
methyl piperidine-4-carboxylate hydrochloride

: 124443-69-2
4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbonyl]-1-piperidinecarboxylic acid,1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 1M aq. NaOH / 2-methyl-propan-2-ol / 48 h

2: 1.) n-BuLi / 1.) -78 deg C, THF, hexane, 15 min 2.) THF, 15 min, -78 deg C

With sodium hydroxide; n-butyllithium; In tert-butyl alcohol;
DOI:10.1021/jo00291a063

Reference yield:

: 51-17-2,79351-71-6
benzoimidazole

: 124443-69-2
4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]carbonyl]-1-piperidinecarboxylic acid,1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF

2: 1.) n-BuLi / 1.) THF

With n-butyllithium; sodium hydride;
DOI:10.1016/S0960-894X(97)10097-X