2-Propenoic acid, 2-methyl-3-(4-methylphenyl)-, methyl ester, (2E)-

Base Information

• Chemical Name: 2-Propenoic acid, 2-methyl-3-(4-methylphenyl)-, methyl ester, (2E)-
• CAS No.: 126356-05-6
• Molecular Formula: C12H14O2
• Molecular Weight: 190.242
• Mol file: 126356-05-6.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 2-methyl-3-(4-methylphenyl)-, methyl ester, (2E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenoic acid, 2-methyl-3-(4-methylphenyl)-, methyl ester, (2E)-

There total 18 articles about 2-Propenoic acid, 2-methyl-3-(4-methylphenyl)-, methyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-tolyl iodide (624-31-7) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → methyl (E)-2-methyl-3-(4-methylphenyl)acrylate (126356-05-6)

Guidance literature:

With trihexyl(tetradecyl)phosphonium chloride; sodium acetate; palladium diacetate; In water; at 50 ℃; for 2h;

DOI:10.1016/j.tetlet.2004.08.103

Reference yield: 94.0%

methyl 2-((hydroxy)(4-methylphenyl)methyl)prop-2-enoate (115240-91-0) → methyl (E)-2-methyl-3-(4-methylphenyl)acrylate (126356-05-6)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at 65 ℃; for 0.166667h;

DOI:10.1016/j.tet.2004.04.087

Reference yield: 93.0%

para-bromotoluene (106-38-7) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → methyl (E)-2-methyl-3-(4-methylphenyl)acrylate (126356-05-6)

Guidance literature:

With sodium acetate; In PEG-400; water; at 80 ℃; for 24h; Atmospheric conditions;

DOI:10.1016/j.tet.2010.10.062

upstream raw materials:

propanoic acid methyl ester

4-methyl-benzaldehyde

methyl 2-((hydroxy)(4-methylphenyl)methyl)prop-2-enoate

methyl 2-(triphenylphosphoranylidene)propionate

Downstream raw materials:

2-methyl-3-p-tolylacrylic acid

-2-methyl-3-(4-methylphenyl)prop-2-enoic acid

C₁₁H₁₂⁽²⁾H₂O

Refernces

• 1、 Ojha, Subhadra,Panda, Niranjan. "Pd-Catalyzed desulfitative arylation of olefins by: N -methoxysulfonamide". supporting information. p. 1292 - 1298. Retrieved 2022/02/19.
• 2、 Savanur, Hemantkumar M.,Kalkhambkar, Rajesh G.,Laali, Kenneth K.. "Piperidine-appended imidazolium ionic liquid as task-specific basic-IL for Suzuki and Heck reactions and for tandem Wittig-Suzuki, Wittig-Heck, Horner-Emmons-Suzuki, and Horner-Emmons-Heck protocols". . p. 150 - 161. Retrieved 2017/06/30.