2-Propenoic acid, 2-methyl-3-(4-methylphenyl)-

Base Information

• Chemical Name: 2-Propenoic acid, 2-methyl-3-(4-methylphenyl)-
• CAS No.: 25860-59-7
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Mol file: 25860-59-7.mol

Synonyms:2-METHYL-3-(4-METHYLPHENYL)-2-PROPENOICACID;p-methyl-;2-PROPENOIC ACID, 2-METHYL-3-(4-METHYLPHENYL)-;

Chemical Property of 2-Propenoic acid, 2-methyl-3-(4-methylphenyl)-

Chemical Property:

• PSA: 37.30000
• LogP: 2.48290

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 2-methyl-3-(4-methylphenyl)-

There total 16 articles about 2-Propenoic acid, 2-methyl-3-(4-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl (E)-2-methyl-3-(p-tolyl)acrylate (119346-67-7) → -2-methyl-3-(4-methylphenyl)prop-2-enoic acid (25860-59-7,66482-35-7,32655-80-4)

Guidance literature:

With water; potassium hydroxide; In ethanol; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.0c02894

Reference yield: 30.0%

4-methyl-benzaldehyde (104-87-0) + propionic acid anhydride (123-62-6) → 2-methyl-3-p-tolylacrylic acid (25860-59-7)

Guidance literature:

propionic acid anhydride; With potassium carbonate; at 0 ℃; for 0.0833333h;

4-methyl-benzaldehyde; at 160 - 180 ℃; for 12h;

DOI:10.1016/j.ejmech.2013.01.012

Reference yield:

methyl 2-methyl-3-p-tolylacrylate → 2-methyl-3-p-tolylacrylic acid (25860-59-7)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2021.128106

upstream raw materials:

methyl (E)-2-methyl-3-(4-methylphenyl)acrylate

4-methyl-benzaldehyde

propionic acid anhydride

methyl 2-(acetoxy(4-methylphenyl)methyl)acrylate

Downstream raw materials:

α-methyl-β-(4-methylphenyl)propionic acid

2,6-dimethylindan-1-one

C₂₃H₂₄O₂

(2E)-2-methyl-3-(4-methylphenyl)-2-propen-1-ol