2-Pyridinecarboxylic acid,5-(trifluoromethyl)-,ethyl ester

Base Information

• Chemical Name: 2-Pyridinecarboxylic acid,5-(trifluoromethyl)-,ethyl ester
• CAS No.: 128072-94-6
• Molecular Formula: C9H8F3NO2
• Molecular Weight: 219.16100
• Hs Code.: 2933399090
• Mol file: 128072-94-6.mol

Synonyms:2-Pyridinecarboxylic acid,5-(trifluoromethyl)-,ethyl ester;ETHYL 5-(TRIFLUOROMETHYL)PICOLINATE;5-(Trifluoromethyl)-2-pyridinecarboxylic acid ethyl ester;ETHYL 5-(TRIFLUOROMETHYL)-2-PYRIDINECARBOXYLATE;

Chemical Property of 2-Pyridinecarboxylic acid,5-(trifluoromethyl)-,ethyl ester

Chemical Property:

• Vapor Pressure: 0.00955mmHg at 25°C
• Melting Point: 45-48oC
• Boiling Point: 264.7oC at 760 mmHg
• Flash Point: 113.9oC
• PSA: 39.19000
• Density: 1.284g/cm3
• LogP: 2.27710
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-(Trifluoromethyl)picolinate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarboxylic acid,5-(trifluoromethyl)-,ethyl ester

There total 1 articles about 2-Pyridinecarboxylic acid,5-(trifluoromethyl)-,ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → ethyl 5-(trifluoromethyl)pyridine-2-carboxylate (128072-94-6)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; sodium acetate; palladium diacetate; at 100 ℃; for 2h; under 11400.8 Torr; Autoclave;

DOI:10.1021/op010012k

upstream raw materials:

ethanol

carbon monoxide

2-chloro-5-trifluoromethylpyridine