6-Methyl-2,4-diphenyl-1,4-dihydroquinazoline

Base Information

• Chemical Name: 6-Methyl-2,4-diphenyl-1,4-dihydroquinazoline
• CAS No.: 128256-22-4
• Molecular Formula: C21H18N2
• Molecular Weight: 298.387
• DSSTox Substance ID: DTXSID70567695
• Nikkaji Number: J865.676B

Synonyms:128256-22-4;6-Methyl-2,4-diphenyl-1,4-dihydroquinazoline;DTXSID70567695

Chemical Property of 6-Methyl-2,4-diphenyl-1,4-dihydroquinazoline

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 298.146998583
• Heavy Atom Count: 23
• Complexity: 418

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)NC(=NC2C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 6-Methyl-2,4-diphenyl-1,4-dihydroquinazoline

There total 4 articles about 6-Methyl-2,4-diphenyl-1,4-dihydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-p-tolyl-2,4-diphenyl-1,3-diazabuta-1,3-diene (136801-71-3) → 6-Methyl-2,4-diphenyl-3,4-dihydro-quinazoline (128256-22-4)

Guidance literature:

With phenyl isothiocyanate; hydroquinone; In benzene; at 80 ℃; for 22h;

DOI:10.1016/S0040-4020(03)01124-4

Reference yield: 79.0%

N-benzylidenephenylsulfonamide (13909-34-7) + 1-p-tolyl-4-dimethylamino-2-phenyl-1,3-diazabutadiene (108228-47-3) → N,N-dimethyl-N′-(phenylsulfonyl)formimidamide (13707-43-2) + 6-methyl-2,4-diphenyl-quinazoline (16107-83-8) + 6-Methyl-2,4-diphenyl-3,4-dihydro-quinazoline (128256-22-4)

Guidance literature:

In toluene; at 110 ℃; for 96h;

DOI:10.3987/com-97-7808

Reference yield: 71.0%

N'-(4-methylphenyl)-N-(triphenylphosphoranylidene)-benzenecarboximidamide (71316-14-8) + benzaldehyde (100-52-7) → 6-Methyl-2,4-diphenyl-3,4-dihydro-quinazoline (128256-22-4)

Guidance literature:

In xylene; for 48h; Heating;

DOI:10.1016/S0040-4039(00)94659-8

upstream raw materials:

N'-(4-methylphenyl)-N-(triphenylphosphoranylidene)-benzenecarboximidamide

benzaldehyde

N-benzylidenephenylsulfonamide

1-p-tolyl-4-dimethylamino-2-phenyl-1,3-diazabutadiene

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