Benzoic acid, 2-chloro-4,5-difluoro-, methyl ester

Base Information

• Chemical Name: Benzoic acid, 2-chloro-4,5-difluoro-, methyl ester
• CAS No.: 128800-36-2
• Molecular Formula: C8H5ClF2O2
• Molecular Weight: 206.576
• Hs Code.: 2916399090
• Mol file: 128800-36-2.mol

Synonyms:Methyl 2-chloro-4,5-difluorobenzoate;2-Chloro-4,5-difluorobenzoic acid methyl ester;

Chemical Property of Benzoic acid, 2-chloro-4,5-difluoro-, methyl ester

Chemical Property:

• Vapor Pressure: 0.0474mmHg at 25°C
• Boiling Point: 236.4oC at 760 mmHg
• Flash Point: 100.2oC
• PSA: 26.30000
• Density: 1.398g/cm3
• LogP: 2.40480

Purity/Quality:

Methyl2-Chloro-4,6-Difluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2-chloro-4,5-difluoro-, methyl ester

There total 5 articles about Benzoic acid, 2-chloro-4,5-difluoro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.6%

methanol (67-56-1) + 2-chloro-4,5-difluorobenzoic acid (110877-64-0) → 2-Chloro-4,5-difluorobenzoic acid methyl ester (128800-36-2)

Guidance literature:

With sulfuric acid; at 60 ℃; for 48h;

Reference yield: 84.0%

2-chloro-4,5-difluorobenzoic acid (110877-64-0) + acetyl chloride (75-36-5) → 2-Chloro-4,5-difluorobenzoic acid methyl ester (128800-36-2)

Guidance literature:

In methanol;

Reference yield: 48.0%

methyl 2,4-dichloro-5-fluorobenzoate → 2-Chloro-4,5-difluorobenzoic acid methyl ester (128800-36-2)

Guidance literature:

upstream raw materials:

2-chloro-4,5-difluorobenzoic acid

acetyl chloride

methanol

sodium methylate

Downstream raw materials:

2-Chloro-4-dimethylamino-5-fluoro-benzoic acid methyl ester

tert-Butyl 4-((5-chloro-2-fluoro-4-(methoxycarbonyl)phenoxy)methyl)-2,2-dimethyloxazolidine-3-carboxylate