(R)-2-((4-BROMOPHENOXY)METHYL)OXIRANE

Base Information

• Chemical Name: (R)-2-((4-BROMOPHENOXY)METHYL)OXIRANE
• CAS No.: 129098-56-2
• Molecular Formula: C9H9BrO2
• Molecular Weight: 229.073
• Mol file: 129098-56-2.mol

Synonyms:

Chemical Property of (R)-2-((4-BROMOPHENOXY)METHYL)OXIRANE

Chemical Property:

• Melting Point: 54.6-55.6 °C
• Boiling Point: 296.0±10.0 °C(Predicted)
• PSA: 21.76000
• Density: 1.527±0.06 g/cm3(Predicted)
• LogP: 2.22670

Purity/Quality:

99%min ^*data from raw suppliers

(R)-2-((4-BROMOPHENOXY)METHYL)OXIRANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-((4-BROMOPHENOXY)METHYL)OXIRANE

There total 3 articles about (R)-2-((4-BROMOPHENOXY)METHYL)OXIRANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.8%

(S)-epichlorohydrin (67843-74-7,24969-06-0,13403-37-7) + 4-bromo-phenol (106-41-2) → (R)-1,2-epoxy-3-(4-bromophenoxy)propane (129098-56-2)

Guidance literature:

With benzyltrimethylammonium chloride; sodium hydroxide; In water; toluene; at 0 ℃;

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 2-((4-bromophenoxy)methyl)oxirane (2212-06-8) → (R)-1,2-epoxy-3-(4-bromophenoxy)propane (129098-56-2) + (R)-4-[(4-bromophenoxy)methyl]-1,3-dioxolan-2-one (950171-38-7) + (S)-4-[(4-bromophenoxy)methyl]-1,3-dioxolan-2-one + (S)-1,2-epoxy-3-(4-bromophenoxy)propane (129098-55-1)

Guidance literature:

With (R,R)-Co(C₆H₁₀(NCHC(COOHex)COCH₃)2); diethylamine; In dichloromethane; at 30 ℃; for 36h; under 15001.5 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1246/bcsj.80.1391

Reference yield:

2-((4-bromophenoxy)methyl)oxirane (2212-06-8) → (R)-3-(4-bromophenoxy)propane-1,2-diol (1186623-24-4) + (R)-1,2-epoxy-3-(4-bromophenoxy)propane (129098-56-2) + (S)-3-(4-bromophenoxy)propane-1,2-diol (1056027-43-0) + (S)-1,2-epoxy-3-(4-bromophenoxy)propane (129098-55-1)

Guidance literature:

With water; In ethanol; at 30 ℃; for 24h; optical yield given as %ee; enantioselective reaction; tryptone/sucrose-supplemented minimal salt medium; Microbiological reaction; Enzymatic reaction;

DOI:10.1016/j.molcatb.2009.12.019

upstream raw materials:

carbon dioxide

2-((4-bromophenoxy)methyl)oxirane

(S)-epichlorohydrin

4-bromo-phenol

Refernces

• 1、 -. "CYCLOPROPANECARBOXYLIC ACID GPR120 MODULATORS". Paragraph 0324; 0325. . Retrieved 2017/09/21.
• 2、 Bala, Neeraj,Chimni, Swapandeep Singh,Saini, Harvinder Singh,Chadha, Bhupinder Singh. "Bacillus alcalophilus MTCC10234 catalyzed enantioselective kinetic resolution of aryl glycidyl ethers". experimental part. p. 128 - 134. Retrieved 2010/10/04.