Ethanol, 2,2-difluoro-1-methoxy-

Base Information

• Chemical Name: Ethanol, 2,2-difluoro-1-methoxy-
• CAS No.: 129660-32-8
• Molecular Formula: C3H6F2O2
• Molecular Weight: 112.076
• Mol file: 129660-32-8.mol

Synonyms:

Chemical Property of Ethanol, 2,2-difluoro-1-methoxy-

Chemical Property:

• PSA: 29.46000
• LogP: 0.21630

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanol, 2,2-difluoro-1-methoxy-

There total 3 articles about Ethanol, 2,2-difluoro-1-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl difluoroacetate (454-31-9) → difluoroethanol (359-13-7) + difluoroacetaldehyde methyl hemiacetal (129660-32-8) + 1-ethoxy-2,2-difluoroethanol (148992-43-2)

Guidance literature:

With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); hydrogen; sodium methylate; In methanol; at 15 ℃; for 8.16667h; under 7500.75 Torr; Pressure;

Reference yield:

difluoroacetic acid methyl ester (433-53-4) + acetic acid (64-19-7,77671-22-8) → difluoroacetaldehyde methyl hemiacetal (129660-32-8) + C4H6F4O2 + C6H10F4O3 + 1-ethoxy-2,2-difluoroethanol (148992-43-2)

Guidance literature:

difluoroacetic acid methyl ester; With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); hydrogen; sodium methylate; In methanol; at 15 ℃; for 8h; under 7500.75 Torr; Large scale;

acetic acid; In methanol; at 66 ℃; under 15.7516 Torr; Reagent/catalyst; Solvent; Pressure; Temperature; Large scale;

Reference yield:

difluoroacetic acid methyl ester (433-53-4) → difluoroethanol (359-13-7) + difluoroacetaldehyde methyl hemiacetal (129660-32-8)

Guidance literature:

With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); hydrogen; sodium methylate; In methanol; at 15 ℃; for 6h; under 7600.51 Torr; Autoclave; Inert atmosphere;

DOI:10.1021/ja403852e

upstream raw materials:

difluoroacetic acid methyl ester

acetic acid

ethyl difluoroacetate

Downstream raw materials:

N-((R)-2,2-difluoro-1-(5-fluoro-1H-indol-3-yl)ethyl)-3,4,5-trimethoxybenzenamine

N-((R)-2,2-difluoro-1-(1H-indol-3-yl)ethyl)-3,4,5-trimethoxybenzenamine