2-O-METHYLTHYMIDINE

Base Information

• Chemical Name: 2-O-METHYLTHYMIDINE
• CAS No.: 37085-48-6
• Molecular Formula: C11H16 N2 O5
• Molecular Weight: 256.258
• Mol file: 37085-48-6.mol

Synonyms:1-(2-Deoxy-b-D-erythro-pentofuranosyl)-2-O-methylthymine;O2-Methylthymidine

Chemical Property of 2-O-METHYLTHYMIDINE

Chemical Property:

• Vapor Pressure: 9.24E-10mmHg at 25°C
• Boiling Point: 444.3°Cat760mmHg
• Flash Point: 222.5°C
• PSA: 93.81000
• Density: 1.49g/cm³
• LogP: -0.79900
• Storage Temp.: ?20°C

Purity/Quality:

97% ^*data from raw suppliers

2-O-METHYLTHYMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-O-METHYLTHYMIDINE

There total 5 articles about 2-O-METHYLTHYMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

5'-O-(p-toluenesulfonyl)thymidine (7253-19-2) → 1-(2-deoxy-β-D-erythro-pentofuranosyl)-2-methoxy-5-methyl-4(1H)-pyrimidinone (37085-48-6)

Guidance literature:

With sodium hydrogencarbonate; In methanol; Heating;

DOI:10.1002/jhet.5570320253

Reference yield:

methanol (67-56-1) + 1-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (25953-14-4,94892-66-7) → 1-(2-deoxy-β-D-erythro-pentofuranosyl)-2-methoxy-5-methyl-4(1H)-pyrimidinone (37085-48-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; for 3h; Yield given; Heating;

DOI:10.1016/S0040-4039(00)76538-5

Reference yield:

methanol (67-56-1) + 5'-O-(p-toluenesulfonyl)thymidine (7253-19-2) → 1-(2-deoxy-β-D-erythro-pentofuranosyl)-2-methoxy-5-methyl-4(1H)-pyrimidinone (37085-48-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; for 3h; Product distribution; Heating; reactions of derivatives with var. alcohols;

DOI:10.1016/S0040-4039(00)76538-5

upstream raw materials:

methanol

1-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

5'-O-(p-toluenesulfonyl)thymidine

3,5'-cyclo-2'-deoxyguanosine

Downstream raw materials:

O²-methyl-5'-DMT-thymidine

2-Deoxy-D-ribose

2-Methoxy-5-methyl-1H-pyrimidin-4-one