4(1H)-Pyrimidinone, 2-methoxy-5-methyl- (9CI)

Base Information

• Chemical Name: 4(1H)-Pyrimidinone, 2-methoxy-5-methyl- (9CI)
• CAS No.: 25902-91-4
• Molecular Formula: C6H8 N2 O2
• Molecular Weight: 140.142
• Hs Code.: 2933599090
• Mol file: 25902-91-4.mol

Synonyms:4(1H)-Pyrimidinone,2-methoxy-5-methyl- (9CI); 2-Methoxy-5-methyl-4-pyrimidinol; O2-Methylthymine

Chemical Property of 4(1H)-Pyrimidinone, 2-methoxy-5-methyl- (9CI)

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 55.24000
• Density: 1.25g/cm³
• LogP: 0.49920

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4(1H)-Pyrimidinone, 2-methoxy-5-methyl- (9CI)

There total 1 articles about 4(1H)-Pyrimidinone, 2-methoxy-5-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-deoxy-β-D-erythro-pentofuranosyl)-2-methoxy-5-methyl-4(1H)-pyrimidinone (37085-48-6) → 2-Deoxy-D-ribose (533-67-5) + 2-Methoxy-5-methyl-1H-pyrimidin-4-one (25902-91-4)

Guidance literature:

With hydrogenchloride; In water; at 32 ℃; Rate constant; pH dependence;

Reference yield: 88.0%

benzyl tosylate (1024-41-5) + 2-methoxy-5-methylpyrimidin-4(3H)-one (25902-91-4) → 4-benzyloxy-2-methoxy-5-methylpyrimidine + 3-benzyl-2-methoxy-5-methyl-4-pyrimidinone (253142-26-6)

Guidance literature:

With lithium hydride; In 1,4-dioxane; at 60 ℃; for 2h;

DOI:10.1016/S0040-4020(99)00736-X

Reference yield: 67.0%

benzyl bromide (100-39-0) + 2-methoxy-5-methylpyrimidin-4(3H)-one (25902-91-4) → 1-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione (6306-73-6) + 1-benzyl-3,5-dimethyl-2,4-pyrimidinedione + 4-benzyloxy-2-methoxy-5-methylpyrimidine + 3-benzyl-2-methoxy-5-methyl-4-pyrimidinone (253142-26-6)

Guidance literature:

With lithium hydride; In 1,4-dioxane; at 60 ℃; for 24h;

DOI:10.1016/S0040-4020(99)00736-X

upstream raw materials:

1-(2-deoxy-β-D-erythro-pentofuranosyl)-2-methoxy-5-methyl-4(1H)-pyrimidinone

Downstream raw materials:

1-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione

3-benzyl-2-methoxy-5-methyl-4-pyrimidinone

3-methylthymine

3-benzyl-5-methyl-2,4(1H)-pyrimidinedione